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- W4246655266 abstract "Injection (i.v.) of 0.5 ml anti-Forssman antiserum to guinea pigs resulted in an irreversible thrombocytopenia (95%) but a transient thrombocytopenia (50%) ensued after 0.2 ml which was complement dependent. During the onset of the thrombocytopenia there was marked platelet sequestration in the vasculature of the lung which was reversed when the circulating platelet count returned to normal. This sequestration was associated with a biphasic bronchospasm which was both platelet and complement dependent. Sulphinpyrazone (100 mg/kg i.v.) administered 30 or 60 min before the antiserum inhibited the thrombocytopenia by 59% and 100% respectively, as we the as the platelet sequestration in the lung and the bronchospasm. Aspirin (100 mg/kg i.v.) and indomethacin (10 mg/kg i.v.) inhibited the bronchospasm but not the thrombocytopenia, while phenylbutazone was inactive in all cases. This model thus distinguishes between sulphinpyrazone and the other inhibitors of prostaglandin synthesis." @default.
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- W4246655266 date "1979-01-01" @default.
- W4246655266 modified "2023-10-18" @default.
- W4246655266 title "Pharmacological Distinction Between Sulphinpyrazone and Inhibitors of Prostaglandin Synthesis" @default.
- W4246655266 doi "https://doi.org/10.1055/s-0039-1684506" @default.
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