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- W4246670561 abstract "Abstract Background: Critically ill patients are not only mechanically ventilated because of ARDS, what kind of ventilation parameter setting is the optimal ventilation strategy for non-ARDS ICU patients? Methods: A retrospective cohort study for non-ARDS patients who received mechanical ventilation (MV), performed univariate, multivariate regression analysis, covariate balancing propensity score and inverse–probability–of–treatment weighting, and machines learning models to predict different outcomes. The included predicted factors are four parameters of mechanical ventilation (Driving pressure (DP) and its mediation of tidal volumes (VT) and positive end-expiratory pressure (PEEP), mechanical power (MP)), and the primary outcome was the ventilator-free days (VFD) at day 28. Results: The study included 2932 patients, low DP, low PEEP and low MP for non-ARDS patients could prolong VFD at day 28, reduce in-hospital mortality and length of hospital stay. However, the VT has no prognostic significance for the population. Among machine learning models with VFD, the randomforest had the best prediction. Conclusions: For non-ARDS patients who receive invasive ventilation for at least 48 hours, low DP, low PEEP and low MP are beneficial to the population. However, the effect of VT is inconclusive." @default.
- W4246670561 created "2022-05-12" @default.
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- W4246670561 date "2020-01-24" @default.
- W4246670561 modified "2023-09-27" @default.
- W4246670561 title "Evaluating the Impact of Ventilator-Associated Parameters on Ventilation Free Days of non-ARDS Patients in ICU." @default.
- W4246670561 doi "https://doi.org/10.21203/rs.2.21795/v1" @default.
- W4246670561 hasPublicationYear "2020" @default.
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