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- W4246671124 abstract "Researchers have found a family of antimalarial agents with a new mode of action. Malaria, transmitted by mosquitoes, is endemic in developing countries, especially in Africa. The World Health Organization estimates there were 214 million malaria cases and 438,000 deaths from the disease last year. Plasmodium falciparum is the parasite responsible for most deaths worldwide. A number of treatments are available, but the microorganism has developed resistance to many of them. When the parasite infects animals, it attacks in three stages: It goes into liver cells first, then enters blood cells, and finally forms gametes that can be transmitted to mosquitoes. Most treatments primarily target parasites in the blood stage, which causes malaria’s symptoms—fever, vomiting, and coma. Stuart L. Schreiber of the Broad Institute and Harvard University and coworkers have now discovered agents that kill the parasite in all three stages in infected mice, curing the mice for up to" @default.
- W4246671124 created "2022-05-12" @default.
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- W4246671124 date "2016-09-12" @default.
- W4246671124 modified "2023-10-16" @default.
- W4246671124 title "Agents hit malaria parasite at all three stages of infection" @default.
- W4246671124 doi "https://doi.org/10.1021/cen-09436-notw4" @default.
- W4246671124 hasPublicationYear "2016" @default.
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