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- W4246699990 abstract "Mild to moderate hypertension usually responds to a β-blocker or a thiazide diuretic. In many patients a combination of the two produces a greater fall in blood pressure than either drug alone, and is often effective in patients who fail to respond to a single drug. 1 The combination also has other advantages. β-Blockers prevent the increase in plasma renin activity which sometimes reduces the hypotensive response to a diuretic. 2 3 β-Blockers at least acutely cause a small rise in plasma potassium which may tend to counteract the mild hypokalaemia produced by thiazides. 4 5 If fluid retention is caused by the β-blocker, 6 the diuretic can reverse it." @default.
- W4246699990 created "2022-05-12" @default.
- W4246699990 date "1981-07-17" @default.
- W4246699990 modified "2023-09-30" @default.
- W4246699990 title "β-Blocker / diuretic combinations for hypertension" @default.
- W4246699990 doi "https://doi.org/10.1136/dtb.19.15.59" @default.
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