Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246703595> ?p ?o ?g. }
- W4246703595 abstract "Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer. Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy failure rates in TNBC significantly outpace other subtypes of breast cancer. Mounting evidence suggests accumulation of therapy resistant Cancer Stem Cell (CSC) populations within TNBCs contributes to poor clinical outcomes. These CSCs are enriched in TNBC compared to non-TNBC breast cancers. The mechanisms underlying CSC accumulation have been well-characterized and discussed in other reviews. In this review, we focus on TNBC-specific mechanisms that allow the expansion and activity of self-renewing CSCs. We highlight cellular signaling pathways and transcription factors, specifically enriched in TNBC over non-TNBC breast cancer, contributing to stemness. We also analyze publicly available single-cell RNA-seq data from basal breast cancer tumors to highlight the potential of emerging bioinformatic approaches in identifying novel drivers of stemness in TNBC and other cancers." @default.
- W4246703595 created "2022-05-12" @default.
- W4246703595 creator A5049858582 @default.
- W4246703595 creator A5053910802 @default.
- W4246703595 creator A5075101326 @default.
- W4246703595 date "2021-01-01" @default.
- W4246703595 modified "2023-10-03" @default.
- W4246703595 title "Regulation of cancer stem cells in triple negative breast cancer" @default.
- W4246703595 cites W1072204632 @default.
- W4246703595 cites W135774829 @default.
- W4246703595 cites W1523439243 @default.
- W4246703595 cites W1542528713 @default.
- W4246703595 cites W1544611835 @default.
- W4246703595 cites W1596473475 @default.
- W4246703595 cites W1660631781 @default.
- W4246703595 cites W1767659940 @default.
- W4246703595 cites W1853160207 @default.
- W4246703595 cites W1868543250 @default.
- W4246703595 cites W1883972812 @default.
- W4246703595 cites W1963501822 @default.
- W4246703595 cites W1964847767 @default.
- W4246703595 cites W1965714535 @default.
- W4246703595 cites W1966227037 @default.
- W4246703595 cites W1966701340 @default.
- W4246703595 cites W1967415928 @default.
- W4246703595 cites W1967615479 @default.
- W4246703595 cites W1968602934 @default.
- W4246703595 cites W1970490725 @default.
- W4246703595 cites W1972232373 @default.
- W4246703595 cites W1973071352 @default.
- W4246703595 cites W1975711182 @default.
- W4246703595 cites W1979006151 @default.
- W4246703595 cites W1979459934 @default.
- W4246703595 cites W1979521500 @default.
- W4246703595 cites W1981088384 @default.
- W4246703595 cites W1981387292 @default.
- W4246703595 cites W1986352281 @default.
- W4246703595 cites W1989805762 @default.
- W4246703595 cites W1995160678 @default.
- W4246703595 cites W1999251458 @default.
- W4246703595 cites W2000098894 @default.
- W4246703595 cites W2001780798 @default.
- W4246703595 cites W2008102732 @default.
- W4246703595 cites W2008202172 @default.
- W4246703595 cites W2011866590 @default.
- W4246703595 cites W2011948097 @default.
- W4246703595 cites W2021536610 @default.
- W4246703595 cites W2022040497 @default.
- W4246703595 cites W2022488821 @default.
- W4246703595 cites W2025915231 @default.
- W4246703595 cites W2026197124 @default.
- W4246703595 cites W2028506395 @default.
- W4246703595 cites W2028593002 @default.
- W4246703595 cites W2030017878 @default.
- W4246703595 cites W2031770999 @default.
- W4246703595 cites W2032755404 @default.
- W4246703595 cites W2035185432 @default.
- W4246703595 cites W2038111996 @default.
- W4246703595 cites W2040430549 @default.
- W4246703595 cites W2042670803 @default.
- W4246703595 cites W2043140203 @default.
- W4246703595 cites W2046769573 @default.
- W4246703595 cites W2047566408 @default.
- W4246703595 cites W2053832323 @default.
- W4246703595 cites W2057139407 @default.
- W4246703595 cites W2061294496 @default.
- W4246703595 cites W2062393465 @default.
- W4246703595 cites W2066808368 @default.
- W4246703595 cites W2069796573 @default.
- W4246703595 cites W2070632651 @default.
- W4246703595 cites W2073534521 @default.
- W4246703595 cites W2075776130 @default.
- W4246703595 cites W2077687384 @default.
- W4246703595 cites W2080457126 @default.
- W4246703595 cites W2083087817 @default.
- W4246703595 cites W2085303926 @default.
- W4246703595 cites W2088035579 @default.
- W4246703595 cites W2092982811 @default.
- W4246703595 cites W2094295288 @default.
- W4246703595 cites W2096027508 @default.
- W4246703595 cites W2096609001 @default.
- W4246703595 cites W2101889783 @default.
- W4246703595 cites W2103165458 @default.
- W4246703595 cites W2103288147 @default.
- W4246703595 cites W2104005622 @default.
- W4246703595 cites W2107503200 @default.
- W4246703595 cites W2107554353 @default.
- W4246703595 cites W2110656750 @default.
- W4246703595 cites W2111713436 @default.
- W4246703595 cites W2114505219 @default.
- W4246703595 cites W2114639059 @default.
- W4246703595 cites W2115504447 @default.
- W4246703595 cites W2115727543 @default.
- W4246703595 cites W2118605519 @default.
- W4246703595 cites W2127438438 @default.
- W4246703595 cites W2127671499 @default.
- W4246703595 cites W2130378759 @default.
- W4246703595 cites W2130811843 @default.
- W4246703595 cites W2131110612 @default.
- W4246703595 cites W2133540952 @default.