Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246707411> ?p ?o ?g. }
- W4246707411 endingPage "275" @default.
- W4246707411 startingPage "265" @default.
- W4246707411 abstract "The role of mechanical and chemical signalling pathways in the organization and function of chromatin is the subject of this review. The mechanical signalling pathway consists of the tissue matrix system that links together the three-dimensional skeletal networks, the extracellular matrix, cytoskeleton, and nuclear matrix. Intermediate filament proteins are associated with nuclear DNA, suggesting that intermediate filaments may have a role in the organization of chromatin. In human hormone-dependent breast cancer cells, the interaction between cytokeratins and chromatin is regulated by estrogens. Transcription factors, histone acetyltransferases, and histone deacetylases, which are associated with the nuclear matrix, are components of the mechanical signalling pathway. Recently, we reported that nuclear matrix-bound human and chicken histone deacetylase 1 is associated with nuclear DNA in situ, suggesting that histone deacetylase has a role in the organization of nuclear DNA. Chemical signalling pathways such as the Ras/mitogen-activated protein kinase (Ras/MAPK) pathway stimulate the activity of kinases that modify transcription factors, nonhistone chromosomal proteins, and histones. The levels of phosphorylated histones are increased in mouse fibroblasts transformed with oncogenes, the products of which stimulate the Ras/MAPK pathway. Histone phosphorylation may lead to decondensation of chromatin, resulting in aberrant gene expression.Key words: histone acetylation, histone phosphorylation, nuclear matrix, cytoskeleton, histone deacetylase, cancer." @default.
- W4246707411 created "2022-05-12" @default.
- W4246707411 creator A5006718236 @default.
- W4246707411 creator A5017330034 @default.
- W4246707411 creator A5024588859 @default.
- W4246707411 creator A5039002471 @default.
- W4246707411 creator A5042529897 @default.
- W4246707411 creator A5045335789 @default.
- W4246707411 creator A5048849645 @default.
- W4246707411 creator A5060124599 @default.
- W4246707411 creator A5087199460 @default.
- W4246707411 date "1999-08-25" @default.
- W4246707411 modified "2023-10-10" @default.
- W4246707411 title "Organization of chromatin in cancer cells: role of signalling pathways" @default.
- W4246707411 cites W1484293540 @default.
- W4246707411 cites W1486257535 @default.
- W4246707411 cites W1486948598 @default.
- W4246707411 cites W1525573602 @default.
- W4246707411 cites W1526931767 @default.
- W4246707411 cites W1542748993 @default.
- W4246707411 cites W1543553963 @default.
- W4246707411 cites W1550565578 @default.
- W4246707411 cites W1590774449 @default.
- W4246707411 cites W1592368907 @default.
- W4246707411 cites W1625884114 @default.
- W4246707411 cites W1635667563 @default.
- W4246707411 cites W1642886682 @default.
- W4246707411 cites W1665024321 @default.
- W4246707411 cites W17703454 @default.
- W4246707411 cites W1783764936 @default.
- W4246707411 cites W1784857457 @default.
- W4246707411 cites W1857890191 @default.
- W4246707411 cites W187992871 @default.
- W4246707411 cites W1921479150 @default.
- W4246707411 cites W1966819401 @default.
- W4246707411 cites W1969967368 @default.
- W4246707411 cites W1973496534 @default.
- W4246707411 cites W1973672022 @default.
- W4246707411 cites W1973912514 @default.
- W4246707411 cites W1975517598 @default.
- W4246707411 cites W1981289453 @default.
- W4246707411 cites W1982619775 @default.
- W4246707411 cites W1985798076 @default.
- W4246707411 cites W1992749632 @default.
- W4246707411 cites W1993260214 @default.
- W4246707411 cites W1996488951 @default.
- W4246707411 cites W1999478984 @default.
- W4246707411 cites W2006466204 @default.
- W4246707411 cites W2015306466 @default.
- W4246707411 cites W2017920584 @default.
- W4246707411 cites W2021588766 @default.
- W4246707411 cites W2026590164 @default.
- W4246707411 cites W2029918551 @default.
- W4246707411 cites W2033763775 @default.
- W4246707411 cites W2034207297 @default.
- W4246707411 cites W2034678566 @default.
- W4246707411 cites W2035209422 @default.
- W4246707411 cites W2036648250 @default.
- W4246707411 cites W2042688084 @default.
- W4246707411 cites W2044051238 @default.
- W4246707411 cites W2044827050 @default.
- W4246707411 cites W2051864256 @default.
- W4246707411 cites W2052746828 @default.
- W4246707411 cites W2053656665 @default.
- W4246707411 cites W2053733046 @default.
- W4246707411 cites W2055597783 @default.
- W4246707411 cites W2056216005 @default.
- W4246707411 cites W2057621066 @default.
- W4246707411 cites W2066917897 @default.
- W4246707411 cites W2067878123 @default.
- W4246707411 cites W2068500972 @default.
- W4246707411 cites W2071323720 @default.
- W4246707411 cites W2073966105 @default.
- W4246707411 cites W2074380974 @default.
- W4246707411 cites W2080487776 @default.
- W4246707411 cites W2082067280 @default.
- W4246707411 cites W2084601812 @default.
- W4246707411 cites W2085905847 @default.
- W4246707411 cites W2087545262 @default.
- W4246707411 cites W2092754786 @default.
- W4246707411 cites W2093117603 @default.
- W4246707411 cites W2094332189 @default.
- W4246707411 cites W2095115211 @default.
- W4246707411 cites W2098536022 @default.
- W4246707411 cites W2109217888 @default.
- W4246707411 cites W2113686599 @default.
- W4246707411 cites W2116359481 @default.
- W4246707411 cites W2125475384 @default.
- W4246707411 cites W2125668148 @default.
- W4246707411 cites W2128884401 @default.
- W4246707411 cites W2144792857 @default.
- W4246707411 cites W2159952125 @default.
- W4246707411 cites W2160771960 @default.
- W4246707411 cites W2163638464 @default.
- W4246707411 cites W2164779343 @default.
- W4246707411 cites W2165477701 @default.
- W4246707411 cites W2166082601 @default.
- W4246707411 cites W2166511050 @default.