FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246716131> ?p ?o ?g. }

• W4246716131 endingPage "850" @default.
• W4246716131 startingPage "843" @default.
• W4246716131 abstract "In the treatment of diabetic nephropathy, ACE inhibitor therapy reduces albumin excretion and slows the rate of decline in glomerular filtration rate (GFR). Our study was designed to investigate whether these effects lay in amelioration of the underlying glomerular structural abnormalities. A total of 54 type 1 diabetic patients with albuminuria and blood pressure (BP) <150/90 mmHg were randomized to receive 10 mg enalapril once daily, 10 mg nifedipine retard twice daily, or placebo in a multicenter double-blind study of 3 years' duration. Renal biopsy was performed at baseline and follow-up, and tissue was analyzed by standard morphometric methods. BP, GFR, albumin excretion rate (AER), and HbA1c were measured every 6 months. Enalapril lowered AER after 6 months by 26% (P < 0.05); however, this reduction was not sustained at 3 years. There was no significant effect of nifedipine or placebo on AER. GFR decreased by a similar average rate of 4.1 ml x min(-1) x year(-1) (95% CI 2.6-5.6) in all three groups. BP and HbA1c were unchanged throughout the study in all groups. At baseline, nearly all biopsies showed classic appearances of diabetic glomerulopathy. There was no detectable effect of enalapril compared with either nifedipine or placebo on renal structure over 3 years. However, we found that patients with increased AER have established glomerulopathy and a progressive average decline in GFR of 4.1 ml x min(-1) x year(-1) in the absence of overt hypertension, and baseline AER appeared predictive of subsequent mesangial volume fraction (r = 0.20, P = 0.0018). In this small cohort of nonhypertensive patients studied for 3 years, disease evolution appears unaffected by treatment with either enalapril or nifedipine." @default.
• W4246716131 created "2022-05-12" @default.
• W4246716131 date "2001-04-01" @default.
• W4246716131 modified "2023-10-13" @default.
• W4246716131 title "Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With Albuminuria" @default.
• W4246716131 cites W1971561750 @default.
• W4246716131 cites W1980919030 @default.
• W4246716131 cites W1991137257 @default.
• W4246716131 cites W1992719998 @default.
• W4246716131 cites W1992808358 @default.
• W4246716131 cites W1994752781 @default.
• W4246716131 cites W1994887713 @default.
• W4246716131 cites W2001049748 @default.
• W4246716131 cites W2004695078 @default.
• W4246716131 cites W2007789292 @default.
• W4246716131 cites W2011427407 @default.
• W4246716131 cites W2034072566 @default.
• W4246716131 cites W2035493509 @default.
• W4246716131 cites W2044276013 @default.
• W4246716131 cites W2045261889 @default.
• W4246716131 cites W2047549364 @default.
• W4246716131 cites W2059996061 @default.
• W4246716131 cites W2064740249 @default.
• W4246716131 cites W2072990621 @default.
• W4246716131 cites W2073935745 @default.
• W4246716131 cites W2078691999 @default.
• W4246716131 cites W2082970155 @default.
• W4246716131 cites W2084142743 @default.
• W4246716131 cites W2087910275 @default.
• W4246716131 cites W2098852944 @default.
• W4246716131 cites W2113601694 @default.
• W4246716131 cites W2136871445 @default.
• W4246716131 cites W2138670606 @default.
• W4246716131 cites W2140015949 @default.
• W4246716131 cites W2157734027 @default.
• W4246716131 cites W2171390294 @default.
• W4246716131 cites W2615684303 @default.
• W4246716131 cites W4231109069 @default.
• W4246716131 cites W4234245694 @default.
• W4246716131 cites W4237181509 @default.
• W4246716131 cites W4238207328 @default.
• W4246716131 cites W4238973071 @default.
• W4246716131 cites W4243054882 @default.
• W4246716131 doi "https://doi.org/10.2337/diabetes.50.4.843" @default.
• W4246716131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11289051" @default.
• W4246716131 hasPublicationYear "2001" @default.
• W4246716131 type Work @default.
• W4246716131 citedByCount "44" @default.
• W4246716131 countsByYear W42467161312014 @default.
• W4246716131 countsByYear W42467161312016 @default.
• W4246716131 countsByYear W42467161312018 @default.
• W4246716131 countsByYear W42467161312019 @default.
• W4246716131 countsByYear W42467161312022 @default.
• W4246716131 crossrefType "journal-article" @default.
• W4246716131 hasBestOaLocation W42467161311 @default.
• W4246716131 hasConcept C126322002 @default.
• W4246716131 hasConcept C126894567 @default.
• W4246716131 hasConcept C134018914 @default.
• W4246716131 hasConcept C142724271 @default.
• W4246716131 hasConcept C159641895 @default.
• W4246716131 hasConcept C204787440 @default.
• W4246716131 hasConcept C27016395 @default.
• W4246716131 hasConcept C27081682 @default.
• W4246716131 hasConcept C2775940317 @default.
• W4246716131 hasConcept C2776174234 @default.
• W4246716131 hasConcept C2779561371 @default.
• W4246716131 hasConcept C2779922275 @default.
• W4246716131 hasConcept C2780091579 @default.
• W4246716131 hasConcept C2780199430 @default.
• W4246716131 hasConcept C555293320 @default.
• W4246716131 hasConcept C71924100 @default.
• W4246716131 hasConcept C84393581 @default.
• W4246716131 hasConceptScore W4246716131C126322002 @default.
• W4246716131 hasConceptScore W4246716131C126894567 @default.
• W4246716131 hasConceptScore W4246716131C134018914 @default.
• W4246716131 hasConceptScore W4246716131C142724271 @default.
• W4246716131 hasConceptScore W4246716131C159641895 @default.
• W4246716131 hasConceptScore W4246716131C204787440 @default.
• W4246716131 hasConceptScore W4246716131C27016395 @default.
• W4246716131 hasConceptScore W4246716131C27081682 @default.
• W4246716131 hasConceptScore W4246716131C2775940317 @default.
• W4246716131 hasConceptScore W4246716131C2776174234 @default.
• W4246716131 hasConceptScore W4246716131C2779561371 @default.
• W4246716131 hasConceptScore W4246716131C2779922275 @default.
• W4246716131 hasConceptScore W4246716131C2780091579 @default.
• W4246716131 hasConceptScore W4246716131C2780199430 @default.
• W4246716131 hasConceptScore W4246716131C555293320 @default.
• W4246716131 hasConceptScore W4246716131C71924100 @default.
• W4246716131 hasConceptScore W4246716131C84393581 @default.
• W4246716131 hasIssue "4" @default.
• W4246716131 hasLocation W42467161311 @default.
• W4246716131 hasLocation W42467161312 @default.
• W4246716131 hasOpenAccess W4246716131 @default.
• W4246716131 hasPrimaryLocation W42467161311 @default.
• W4246716131 hasRelatedWork W1507850986 @default.
• W4246716131 hasRelatedWork W1942989552 @default.
• W4246716131 hasRelatedWork W20644872 @default.
• W4246716131 hasRelatedWork W2085753441 @default.

• next