Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246806063> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4246806063 endingPage "52" @default.
- W4246806063 startingPage "47" @default.
- W4246806063 abstract "This chapter describes the mechanism of action of anorexigenic agents. Sufficient evidence has been accumulated to fix the probable locus of their suppressant action on the lateral nuclei or feeding center of the hypothalamus. Gold-thioglucose obese mice are not refractory to the anorexigenic effect of amphetamine and, therefore, not dependent on a ventromedial inhibitory system suggesting that the lateral hypothalamic feeding center is involved in the anorexigenic effects of amphetamine. Inhibition of gold-thioglucose induced obesity by the glucose inhibitor 2-deoxy-D-glucose or its amino analog led to the conclusion that these inhibitors interact with cells in the satiety center. A dose-dependent increase, in electrical stimulation of the lateral hypothalamus, necessary to elicit eating in food-satiated rats, was clearly shown for amphetamine, phenmetrazine, methamphetamine, chlorphentermine, and diethylpropion. The duration of effect also tended to be dose-dependent for the tested drugs, except amphetamine and methamphetamine. The thiophene derivative and related amino modifications were claimed to have anorexigenic activity comparable to amphetamine with much less central nervous system stimulation. A chloro-substituted derivative was reported to be one-fifth as potent as diethyl-propion in decreasing food intake in dog." @default.
- W4246806063 created "2022-05-12" @default.
- W4246806063 creator A5047480533 @default.
- W4246806063 date "1968-01-01" @default.
- W4246806063 modified "2023-09-25" @default.
- W4246806063 title "Chapter 5. Anorexigenic Agents" @default.
- W4246806063 cites W141583654 @default.
- W4246806063 cites W1567162986 @default.
- W4246806063 cites W1569979354 @default.
- W4246806063 cites W2001805711 @default.
- W4246806063 cites W2014397978 @default.
- W4246806063 cites W2035158930 @default.
- W4246806063 cites W2035165450 @default.
- W4246806063 cites W2041128480 @default.
- W4246806063 cites W2046770262 @default.
- W4246806063 cites W2078158268 @default.
- W4246806063 cites W2078878899 @default.
- W4246806063 cites W2089352344 @default.
- W4246806063 cites W2109236010 @default.
- W4246806063 cites W2132425431 @default.
- W4246806063 cites W2323464578 @default.
- W4246806063 cites W2329115678 @default.
- W4246806063 cites W2399520477 @default.
- W4246806063 cites W2589816095 @default.
- W4246806063 cites W41987826 @default.
- W4246806063 cites W4361767012 @default.
- W4246806063 cites W4366747658 @default.
- W4246806063 doi "https://doi.org/10.1016/s0065-7743(08)61309-3" @default.
- W4246806063 hasPublicationYear "1968" @default.
- W4246806063 type Work @default.
- W4246806063 citedByCount "0" @default.
- W4246806063 crossrefType "book-chapter" @default.
- W4246806063 hasAuthorship W4246806063A5047480533 @default.
- W4246806063 hasConcept C126322002 @default.
- W4246806063 hasConcept C134018914 @default.
- W4246806063 hasConcept C185592680 @default.
- W4246806063 hasConcept C24998067 @default.
- W4246806063 hasConcept C2777003273 @default.
- W4246806063 hasConcept C2777193897 @default.
- W4246806063 hasConcept C2780376393 @default.
- W4246806063 hasConcept C513476851 @default.
- W4246806063 hasConcept C71924100 @default.
- W4246806063 hasConcept C98274493 @default.
- W4246806063 hasConceptScore W4246806063C126322002 @default.
- W4246806063 hasConceptScore W4246806063C134018914 @default.
- W4246806063 hasConceptScore W4246806063C185592680 @default.
- W4246806063 hasConceptScore W4246806063C24998067 @default.
- W4246806063 hasConceptScore W4246806063C2777003273 @default.
- W4246806063 hasConceptScore W4246806063C2777193897 @default.
- W4246806063 hasConceptScore W4246806063C2780376393 @default.
- W4246806063 hasConceptScore W4246806063C513476851 @default.
- W4246806063 hasConceptScore W4246806063C71924100 @default.
- W4246806063 hasConceptScore W4246806063C98274493 @default.
- W4246806063 hasLocation W42468060631 @default.
- W4246806063 hasOpenAccess W4246806063 @default.
- W4246806063 hasPrimaryLocation W42468060631 @default.
- W4246806063 hasRelatedWork W2005622725 @default.
- W4246806063 hasRelatedWork W2034768996 @default.
- W4246806063 hasRelatedWork W2046931788 @default.
- W4246806063 hasRelatedWork W2051488242 @default.
- W4246806063 hasRelatedWork W2054992011 @default.
- W4246806063 hasRelatedWork W2057602894 @default.
- W4246806063 hasRelatedWork W2060618991 @default.
- W4246806063 hasRelatedWork W2064416809 @default.
- W4246806063 hasRelatedWork W2122221387 @default.
- W4246806063 hasRelatedWork W2163700154 @default.
- W4246806063 isParatext "false" @default.
- W4246806063 isRetracted "false" @default.
- W4246806063 workType "book-chapter" @default.