Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246864789> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4246864789 endingPage "300" @default.
- W4246864789 startingPage "293" @default.
- W4246864789 abstract "Th1-response plays a crucial role in determining pathogenesis of organ-specific autoimmune diseases. It is believed that both IL-12 and INF-α are initiators to regulate Th1- response. In our experimental autoimmune uveitis (EAU) model, both Lewis and Fischer 344 rats share the same MHC class II molecules, while Lewis rat is EAU susceptible and Fischer 344 rat is EAU resistant. However, under the same condition of immunization, if pertussis toxin (PTX) was injected intraperitoneally as an additional adjuvant, Fischer 344 rat can develop EAU. In this study we investigate which mechanisms are involved in the induction of EAU in CFA+R16+PTX-treated (CRP-treated) Fischer 344 rats. In vivo and in vitro data demonstrated that Th1-cytokine, IFN-γ mRNA expression was significantly increased in disease target tissue-eyes and in draining lymph node cells of CRP-treated Fischer 344 rat. When IL-12 and IFN-α mRNA expression were compared in the experimental groups, only IFN-α mRNA expression was associated with EAU development. To distinguish the sources of IFN-α producing cells, it was observed that IFN-α expression was mainly produced by macrophages. It was further confirmed that normal macrophage from Fischer 344 rat was able to produce significant IFN-α in the presence of PTX. The data strongly suggested that IFN-α might be involved in initiating Th1-cell differentiation and in turn contribute to the induction of EAU. High IFN-a expression induced by PTX may represent a novel pathway to initiate Th1 response in Fischer 344 rat." @default.
- W4246864789 created "2022-05-12" @default.
- W4246864789 creator A5023988743 @default.
- W4246864789 creator A5077235896 @default.
- W4246864789 creator A5083839076 @default.
- W4246864789 creator A5089372773 @default.
- W4246864789 date "2001-12-01" @default.
- W4246864789 modified "2023-10-07" @default.
- W4246864789 title "High IFN-α expression is associated with the induction of experimental autoimmune uveitis (EAU) in Fischer 344 rat" @default.
- W4246864789 cites W1967912592 @default.
- W4246864789 cites W2003579303 @default.
- W4246864789 cites W2004858718 @default.
- W4246864789 cites W2056859114 @default.
- W4246864789 cites W2063053561 @default.
- W4246864789 cites W2072114342 @default.
- W4246864789 cites W2077317959 @default.
- W4246864789 cites W2078388864 @default.
- W4246864789 cites W2082566286 @default.
- W4246864789 cites W2089077517 @default.
- W4246864789 cites W2152729998 @default.
- W4246864789 cites W2172466148 @default.
- W4246864789 doi "https://doi.org/10.1038/sj.cr.293" @default.
- W4246864789 hasPublicationYear "2001" @default.
- W4246864789 type Work @default.
- W4246864789 citedByCount "0" @default.
- W4246864789 crossrefType "journal-article" @default.
- W4246864789 hasAuthorship W4246864789A5023988743 @default.
- W4246864789 hasAuthorship W4246864789A5077235896 @default.
- W4246864789 hasAuthorship W4246864789A5083839076 @default.
- W4246864789 hasAuthorship W4246864789A5089372773 @default.
- W4246864789 hasBestOaLocation W42468647891 @default.
- W4246864789 hasConcept C104317684 @default.
- W4246864789 hasConcept C105580179 @default.
- W4246864789 hasConcept C150903083 @default.
- W4246864789 hasConcept C159654299 @default.
- W4246864789 hasConcept C17991360 @default.
- W4246864789 hasConcept C203014093 @default.
- W4246864789 hasConcept C207001950 @default.
- W4246864789 hasConcept C2776178377 @default.
- W4246864789 hasConcept C2776194053 @default.
- W4246864789 hasConcept C2778690821 @default.
- W4246864789 hasConcept C2779075594 @default.
- W4246864789 hasConcept C2780841837 @default.
- W4246864789 hasConcept C2780942790 @default.
- W4246864789 hasConcept C55493867 @default.
- W4246864789 hasConcept C86803240 @default.
- W4246864789 hasConceptScore W4246864789C104317684 @default.
- W4246864789 hasConceptScore W4246864789C105580179 @default.
- W4246864789 hasConceptScore W4246864789C150903083 @default.
- W4246864789 hasConceptScore W4246864789C159654299 @default.
- W4246864789 hasConceptScore W4246864789C17991360 @default.
- W4246864789 hasConceptScore W4246864789C203014093 @default.
- W4246864789 hasConceptScore W4246864789C207001950 @default.
- W4246864789 hasConceptScore W4246864789C2776178377 @default.
- W4246864789 hasConceptScore W4246864789C2776194053 @default.
- W4246864789 hasConceptScore W4246864789C2778690821 @default.
- W4246864789 hasConceptScore W4246864789C2779075594 @default.
- W4246864789 hasConceptScore W4246864789C2780841837 @default.
- W4246864789 hasConceptScore W4246864789C2780942790 @default.
- W4246864789 hasConceptScore W4246864789C55493867 @default.
- W4246864789 hasConceptScore W4246864789C86803240 @default.
- W4246864789 hasIssue "4" @default.
- W4246864789 hasLocation W42468647891 @default.
- W4246864789 hasOpenAccess W4246864789 @default.
- W4246864789 hasPrimaryLocation W42468647891 @default.
- W4246864789 hasRelatedWork W1600496839 @default.
- W4246864789 hasRelatedWork W1677381867 @default.
- W4246864789 hasRelatedWork W1759492826 @default.
- W4246864789 hasRelatedWork W2150138097 @default.
- W4246864789 hasRelatedWork W2357748045 @default.
- W4246864789 hasRelatedWork W2412960471 @default.
- W4246864789 hasRelatedWork W2970025364 @default.
- W4246864789 hasRelatedWork W3008477780 @default.
- W4246864789 hasRelatedWork W3213005815 @default.
- W4246864789 hasRelatedWork W2120914721 @default.
- W4246864789 hasVolume "11" @default.
- W4246864789 isParatext "false" @default.
- W4246864789 isRetracted "false" @default.
- W4246864789 workType "article" @default.