Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246871657> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4246871657 endingPage "1366" @default.
- W4246871657 startingPage "1366" @default.
- W4246871657 abstract "Previously, we showed that CD137 ligand (CD137L; AKA 4-1BBL) contributes to the development of behavioral hypersensitivity and functional recovery in mice following peripheral nerve injury-induced neuropathic pain. Mice that lack CD137L showed reduced sensory sensitivity and faster functional recovery. Here, we sought to further investigate the potential involvement of lumbar spinal cord microglial responses in CD137L-mediated behavioral changes following sciatic nerve crush. Lumbar spinal cord microglia were isolated from both wild type B6 and CD137L knockout (KO)_B6 mice via positive selection based on CD11b expression using magnetic beads at days 0 (naïve), 3, 7, 14, 28 and 56 following sciatic nerve crush or sham surgery. Following RNA extraction, qRT-PCR were performed to examine cytokine/chemokine expression in isolated microglia. Our preliminary results suggest that male mice had more measurable cytokine/chemokine responses than female mice. Despite that many cytokines are below the detection levels, we were able to observe increased expression of several chemokines, CCL2, CCL3, CCL4 and CCL5 in microglia from CD137L KO mice, which appeared to peak early following injury (Days 3–14) than that in microglia isolated from WT mice. Future study will determine the involvement of microglial chemokine responses in CD137L mediated sensory hypersensitivity and delayed functional recovery following peripheral nerve injury." @default.
- W4246871657 created "2022-05-12" @default.
- W4246871657 creator A5078935876 @default.
- W4246871657 date "1956-12-08" @default.
- W4246871657 modified "2023-09-25" @default.
- W4246871657 title "Herpes Zoster" @default.
- W4246871657 doi "https://doi.org/10.1136/bmj.2.5005.1366-a" @default.
- W4246871657 hasPublicationYear "1956" @default.
- W4246871657 type Work @default.
- W4246871657 citedByCount "0" @default.
- W4246871657 crossrefType "journal-article" @default.
- W4246871657 hasAuthorship W4246871657A5078935876 @default.
- W4246871657 hasConcept C116484652 @default.
- W4246871657 hasConcept C118552586 @default.
- W4246871657 hasConcept C13373296 @default.
- W4246871657 hasConcept C203014093 @default.
- W4246871657 hasConcept C2776090121 @default.
- W4246871657 hasConcept C2776880756 @default.
- W4246871657 hasConcept C2776914184 @default.
- W4246871657 hasConcept C2779830541 @default.
- W4246871657 hasConcept C2780775167 @default.
- W4246871657 hasConcept C2781149210 @default.
- W4246871657 hasConcept C2909382400 @default.
- W4246871657 hasConcept C42219234 @default.
- W4246871657 hasConcept C5858377 @default.
- W4246871657 hasConcept C71924100 @default.
- W4246871657 hasConcept C79484868 @default.
- W4246871657 hasConcept C8891405 @default.
- W4246871657 hasConceptScore W4246871657C116484652 @default.
- W4246871657 hasConceptScore W4246871657C118552586 @default.
- W4246871657 hasConceptScore W4246871657C13373296 @default.
- W4246871657 hasConceptScore W4246871657C203014093 @default.
- W4246871657 hasConceptScore W4246871657C2776090121 @default.
- W4246871657 hasConceptScore W4246871657C2776880756 @default.
- W4246871657 hasConceptScore W4246871657C2776914184 @default.
- W4246871657 hasConceptScore W4246871657C2779830541 @default.
- W4246871657 hasConceptScore W4246871657C2780775167 @default.
- W4246871657 hasConceptScore W4246871657C2781149210 @default.
- W4246871657 hasConceptScore W4246871657C2909382400 @default.
- W4246871657 hasConceptScore W4246871657C42219234 @default.
- W4246871657 hasConceptScore W4246871657C5858377 @default.
- W4246871657 hasConceptScore W4246871657C71924100 @default.
- W4246871657 hasConceptScore W4246871657C79484868 @default.
- W4246871657 hasConceptScore W4246871657C8891405 @default.
- W4246871657 hasIssue "5005" @default.
- W4246871657 hasLocation W42468716571 @default.
- W4246871657 hasOpenAccess W4246871657 @default.
- W4246871657 hasPrimaryLocation W42468716571 @default.
- W4246871657 hasRelatedWork W112705378 @default.
- W4246871657 hasRelatedWork W2003547082 @default.
- W4246871657 hasRelatedWork W2078534511 @default.
- W4246871657 hasRelatedWork W2300928585 @default.
- W4246871657 hasRelatedWork W2385580656 @default.
- W4246871657 hasRelatedWork W2406516931 @default.
- W4246871657 hasRelatedWork W3049384129 @default.
- W4246871657 hasRelatedWork W4246871657 @default.
- W4246871657 hasRelatedWork W4313365730 @default.
- W4246871657 hasRelatedWork W4313373344 @default.
- W4246871657 hasVolume "2" @default.
- W4246871657 isParatext "false" @default.
- W4246871657 isRetracted "false" @default.
- W4246871657 workType "article" @default.