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- W4246877897 abstract "Nonimmobilizers (previously called nonanesthetics) do not prevent movement in response to a noxious stimulus, even at doses predicted to produce anesthesia.We hypothesized they would also lack antinociceptive effects. We tested this prediction using the tail-flick latency (TFL) test. As predicted, the two nonimmobilizers tested (1,2-dichlorohexafluorocyclobutane and perfluoropentane) did not alter TFL, whereas desflurane and nitrous oxide both lengthened TFL (nitrous oxide at a lower minimum alveolar anesthetic concentration [MAC]-multiple than desflurane). In addition, we found that 0.1 MAC desflurane had a hyperalgesic effect (shortened TFL). Implications: We studied the response of animals inhaling anesthetics or nonimmobilizers (compounds predicted to be anesthetics from the Meyer-Overton relation) to painful stimuli. Nonimmobilizers had no effect on these responses; at a low partial pressure, desflurane was hyperalgesic; nitrous oxide and, at higher partial pressures, desflurane were antinociceptive. (Anesth Analg 1998;86:629-34)" @default.
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- W4246877897 date "1998-03-01" @default.
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- W4246877897 title "Desflurane and Nitrous Oxide, but Not Nonimmobilizers, Affect Nociceptive Responses" @default.
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- W4246877897 doi "https://doi.org/10.1213/00000539-199803000-00036" @default.
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