Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246895183> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4246895183 endingPage "2678" @default.
- W4246895183 startingPage "2671" @default.
- W4246895183 abstract "The treatment of cancer with lymphokine-activated killer (LAK) cells in conjunction with high-dose interleukin-2 (IL-2) has been limited by the toxicity of IL-2 and the narrow range of tumors that respond to therapy. Cytokines that are capable of augmenting lower doses of IL-2 are, therefore, a major focus of research. We report here that granulocyte-macrophage colony-stimulating factor (GM-CSF) can augment low-dose IL-2 LAK induction from murine splenocytes. Anti-tumor necrosis factor alpha (anti-TNF alpha) or anti-interferon gamma (anti- IFN gamma) monoclonal antibodies did not inhibit (IL-2 + GM-CSF)- induced LAK generation, indicating that GM-CSF augmentation does not require TNF alpha or IFN gamma activity. Depletion of natural killer cells before culture did not inhibit low-dose IL-2-induced LAK generation or the ability of GM-CSF to augment LAK generation. In contrast, depletion of both CD4+ and CD8+ T cells before culture inhibited the generation of LAK activity. However, depletion of only CD4+ T cells, or only CD8+ T cells, did not inhibit the generation of IL-2 or (IL-2 + GM-CSF) LAK activity. These results suggest that LAK precursors are present in both the CD4+ and CD8+ T-cell populations and suggest that the addition of GM-CSF to low-dose IL-2 may result in the generation of T-derived LAK cells." @default.
- W4246895183 created "2022-05-12" @default.
- W4246895183 creator A5060162446 @default.
- W4246895183 creator A5065478968 @default.
- W4246895183 creator A5075592600 @default.
- W4246895183 creator A5089979088 @default.
- W4246895183 date "1993-05-15" @default.
- W4246895183 modified "2023-09-27" @default.
- W4246895183 title "Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction" @default.
- W4246895183 doi "https://doi.org/10.1182/blood.v81.10.2671.bloodjournal81102671" @default.
- W4246895183 hasPublicationYear "1993" @default.
- W4246895183 type Work @default.
- W4246895183 citedByCount "0" @default.
- W4246895183 crossrefType "journal-article" @default.
- W4246895183 hasAuthorship W4246895183A5060162446 @default.
- W4246895183 hasAuthorship W4246895183A5065478968 @default.
- W4246895183 hasAuthorship W4246895183A5075592600 @default.
- W4246895183 hasAuthorship W4246895183A5089979088 @default.
- W4246895183 hasBestOaLocation W42468951831 @default.
- W4246895183 hasConcept C129374314 @default.
- W4246895183 hasConcept C154317977 @default.
- W4246895183 hasConcept C167672396 @default.
- W4246895183 hasConcept C17991360 @default.
- W4246895183 hasConcept C202751555 @default.
- W4246895183 hasConcept C203014093 @default.
- W4246895183 hasConcept C2777371288 @default.
- W4246895183 hasConcept C2777478134 @default.
- W4246895183 hasConcept C2778690821 @default.
- W4246895183 hasConcept C28651165 @default.
- W4246895183 hasConcept C49382859 @default.
- W4246895183 hasConcept C502942594 @default.
- W4246895183 hasConcept C55493867 @default.
- W4246895183 hasConcept C86803240 @default.
- W4246895183 hasConcept C8891405 @default.
- W4246895183 hasConceptScore W4246895183C129374314 @default.
- W4246895183 hasConceptScore W4246895183C154317977 @default.
- W4246895183 hasConceptScore W4246895183C167672396 @default.
- W4246895183 hasConceptScore W4246895183C17991360 @default.
- W4246895183 hasConceptScore W4246895183C202751555 @default.
- W4246895183 hasConceptScore W4246895183C203014093 @default.
- W4246895183 hasConceptScore W4246895183C2777371288 @default.
- W4246895183 hasConceptScore W4246895183C2777478134 @default.
- W4246895183 hasConceptScore W4246895183C2778690821 @default.
- W4246895183 hasConceptScore W4246895183C28651165 @default.
- W4246895183 hasConceptScore W4246895183C49382859 @default.
- W4246895183 hasConceptScore W4246895183C502942594 @default.
- W4246895183 hasConceptScore W4246895183C55493867 @default.
- W4246895183 hasConceptScore W4246895183C86803240 @default.
- W4246895183 hasConceptScore W4246895183C8891405 @default.
- W4246895183 hasIssue "10" @default.
- W4246895183 hasLocation W42468951831 @default.
- W4246895183 hasOpenAccess W4246895183 @default.
- W4246895183 hasPrimaryLocation W42468951831 @default.
- W4246895183 hasRelatedWork W12044261 @default.
- W4246895183 hasRelatedWork W12318454 @default.
- W4246895183 hasRelatedWork W17427955 @default.
- W4246895183 hasRelatedWork W18854528 @default.
- W4246895183 hasRelatedWork W19586471 @default.
- W4246895183 hasRelatedWork W20021324 @default.
- W4246895183 hasRelatedWork W23129031 @default.
- W4246895183 hasRelatedWork W32399917 @default.
- W4246895183 hasRelatedWork W4313372 @default.
- W4246895183 hasRelatedWork W9510583 @default.
- W4246895183 hasVolume "81" @default.
- W4246895183 isParatext "false" @default.
- W4246895183 isRetracted "false" @default.
- W4246895183 workType "article" @default.