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- W4246918497 abstract "Abstract A series of tubular molecules with different lengths have been synthesized by attaching Trp‐incorporated peptides to the pillar[5]arene backbone. The tubular molecules are able to insert into the lipid bilayer to form unimolecular transmembrane channels. One of the channels has been revealed to specifically insert into the bilayer of the Gram‐positive bacteria. In contrast, this channel cannot insert into the membranes of the mammalian rat erythrocytes even at the high concentration of 100 μ m . It was further demonstrated that, as a result of this high membrane selectivity, the channel exhibits efficient antimicrobial activity for the Gram‐positive bacteria and very low hemolytic toxicity for mammalian erythrocytes." @default.
- W4246918497 created "2022-05-12" @default.
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- W4246918497 date "2017-02-07" @default.
- W4246918497 modified "2023-10-16" @default.
- W4246918497 title "Synthetic Channel Specifically Inserts into the Lipid Bilayer of Gram‐Positive Bacteria but not that of Mammalian Erythrocytes" @default.
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- W4246918497 doi "https://doi.org/10.1002/ange.201612093" @default.
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