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- W4246920057 abstract "Abstract Background: Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. Methods: In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi). Seventeen dogs were randomized into two groups (treated with BChEi and untreated) and followed for 6 months at regular check-ups. The dogs’ cognitive status was determined by a CADES questionnaire and two cognitive tests. Results: In dogs with moderate cognitive impairment, treatment caused significant improvement in the clinical rating of cognitive abilities and the performance-based tests of cognitive functioning when compared to the untreated group (p < 0.001). Dogs treated with BChEi showed markedly improved cognitive function with enhanced quality of life. No side effects were observed in the treated dogs with moderate cognitive impairment. Conclusions: Novel BChE inhibitor is a promising candidate for treating CCD, and might be an interesting canidate drug for the treatment of Alzheimer disease in humans." @default.
- W4246920057 created "2022-05-12" @default.
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- W4246920057 date "2020-12-04" @default.
- W4246920057 modified "2023-10-17" @default.
- W4246920057 title "Treatment of Canine Cognitive Dysfunction With Novel Butyrylcholinesterase Inhibitor" @default.
- W4246920057 doi "https://doi.org/10.21203/rs.3.rs-118291/v1" @default.
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