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- W4246966102 abstract "Five different peptides (P1: 84′95; P2: 152′166; P3: 52′63; P4: 7′23; P5: 110′123) homologous to relatively hydrophilic regions of human erythropoietin (huEpo) have been synthesized to identify biologically active domains of the hormone. All peptides were able to induce high titers of peptide-specific antibodies in rabbits. Antisera from rabbits induced by recombinant huEpo (rhuEpo) contained a relatively high amount of antibodies preferentially directed against three peptides (P2, P4, and P5), of which P4 comprised the amino-terminal region, P2 the carboxyl-terminus, and P5 an interior region previously described as the receptor-binding site. The same three peptides were able to induce rhuEpo-specific antibodies, whereas P1 and P3 lacked this activity. Only peptide-P2-induced antisera inhibited the biologic activity of rhuEpo in a cell proliferation assay, indicating that the carboxyl-terminal region of the molecule is essentially involved in the biologic function of rhuEpo." @default.
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- W4246966102 date "1991-03-15" @default.
- W4246966102 modified "2023-09-26" @default.
- W4246966102 title "Evidence for the location of the receptor-binding site of human erythropoietin at the carboxyl-terminal domain" @default.
- W4246966102 doi "https://doi.org/10.1182/blood.v77.6.1203.bloodjournal7761203" @default.
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