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- W4246987907 abstract "The effects of the selective inhibitor of calcineurin, cyclosporin A-cyclophilin A (CC) complex on the desensitization kinetics of GABA A receptors was studied in acutely dissociated hippocampal neurons, using the patch clamp technique in the whole cell configuration. In control conditions, the decay of GABA-evoked current could be fitted by a biexponential function having time constants of 0.65 ± 0.24 s and 3.75 ± 2 s. The plateau to peak ratio was 0.087 ± 0.034. Recovery from desensitization was obtained in more than 2 min. In cells dialyzed with the CC complex, the decay of the currents could be fitted with the sum of two exponentials having time constants similar to controls (0.81 ± 0.47 s and 3.62 ± 2.1 s), but the percentage of the fast component was smaller. The plateau to peak ratio was significantly larger than control (0.185 ± 0.07). With CC complex, recovery from desensitization was completed in almost 30 s. The cyclosporin A derivative PSC 833, which does not inhibit calcineurin, did not affect desensitization kinetics. These results suggest that phosphatase 213 regulates desensitization of GABA A receptors." @default.
- W4246987907 created "2022-05-12" @default.
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- W4246987907 date "1996-09-06" @default.
- W4246987907 modified "2023-10-03" @default.
- W4246987907 title "The calcineurin inhibitor cyclosporin A-cyclophilin A complex reduces desensitization of GABAA-mediated responses in acutely dissociated rat hippocampal neurons" @default.
- W4246987907 doi "https://doi.org/10.1016/s0304-3940(96)12957-8" @default.
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