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- W4247000284 abstract "Prion diseases are a group of fatal neurodegenerative disorders that affect humans and animals. They are characterized by the accumulation in the central nervous system of a pathological form of the host-encoded prion protein (PrP C ). The prion protein is a membrane glycoprotein that consists of two domains: a globular, structured C-terminus and an unstructured N-terminus. The N-terminal part of the protein is involved in different functions in both health and disease. In the present work we discuss the production and biochemical characterization of a panel of four monoclonal antibodies (mAbs) against the distal N-terminus of PrP C using a well-established methodology based on the immunization of Prnp 0/0 mice. Additionally, we show their ability to block prion (PrP Sc ) replication at nanomolar concentrations in a cell culture model of prion infection. These mAbs represent a promising tool for prion diagnostics and for studying the physiological role of the N-terminal domain of PrP C ." @default.
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- W4247000284 date "2014-12-14" @default.
- W4247000284 modified "2023-10-03" @default.
- W4247000284 title "Characterization of four new monoclonal antibodies against the distal N-terminal region of PrPc" @default.
- W4247000284 doi "https://doi.org/10.7287/peerj.preprints.694v1" @default.
- W4247000284 hasPublicationYear "2014" @default.
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