Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247008721> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4247008721 abstract "Abstract Background: There have been various publications stating that IL-10 gene polymorphism is connected with the risk of breast cancer.This study was to further evaluate the association between IL-10 gene polymorphism and breast cancer (BC). Methods: Articles from PubMed, Web of Knowledge, Embase, CNKI databases, China biomedical (CBM), and Google Scholar before March 29, 2020. The data was analyzed by Revman5.3 and Stata 12.0 software, and the strength of the association was identified using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results : A total of 23 studies (7250 cancer cases and 7675 case-free controls) were eligible for the mate-analysis. The results show that IL-10 gene polymorphisms has no association with BC risk in any genetic model of the general population. However, there is significantly correlated with BC risk based on subgroup analysis by ethnicity: rs1800896 polymorphism are significantly associated with the risk of BC in Asian population based on the four models (G vs. A: OR= 0.78, 95% CI=0.65-0.95, P = 0.01; GG vs. AA: OR=0.51, 95% CI=0.31-0.84, P =0.007; GA vs. AA: OR=0.6, 95% CI=0.44-0.81, P =0.0009; GG+GA vs. AA: OR=0.6, 95% CI=0.45-0.81, P = 0.0007); rs1800871 polymorphism has association with BC risk in Caucasian population based on the Heterozygous model (CT vs. TT: OR=1.8, 95% CI =1.03-3.13, P =0.04). rs1800872 homozygous model was associated with the BC risk in Asians(AA vs CC: OR=0.74, 95%CI =0.55-0.99, P =0.04), and allelic model was associated with BC risk among Asians (A vs C: OR= 0.85, 95% CI =0.74-0.98, P = 0.03) and among Caucasians (A vs C: OR= 0.65, 95% CI 0.43-0.98, P =0.04). Conclusion : IL-10 gene polymorphism rs1800896 and rs1800872 significantly increased the risk of breast cancer in Asians, while rs1800871 was associated with the risk of breast cancer in Caucasians. Therefore, vulnerable individuals can be identified by genotypic characteristics, and the diseases can be prevented through interventions aimed at high-risk groups." @default.
- W4247008721 created "2022-05-12" @default.
- W4247008721 creator A5007728943 @default.
- W4247008721 creator A5029262883 @default.
- W4247008721 creator A5030081153 @default.
- W4247008721 creator A5036413944 @default.
- W4247008721 creator A5074042101 @default.
- W4247008721 date "2021-06-10" @default.
- W4247008721 modified "2023-09-29" @default.
- W4247008721 title "Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) with Breast Cancer Risk: an Updated Meta-Analysis Based on Different Ethnic Groups" @default.
- W4247008721 doi "https://doi.org/10.21203/rs.3.rs-587891/v1" @default.
- W4247008721 hasPublicationYear "2021" @default.
- W4247008721 type Work @default.
- W4247008721 citedByCount "0" @default.
- W4247008721 crossrefType "posted-content" @default.
- W4247008721 hasAuthorship W4247008721A5007728943 @default.
- W4247008721 hasAuthorship W4247008721A5029262883 @default.
- W4247008721 hasAuthorship W4247008721A5030081153 @default.
- W4247008721 hasAuthorship W4247008721A5036413944 @default.
- W4247008721 hasAuthorship W4247008721A5074042101 @default.
- W4247008721 hasBestOaLocation W42470087212 @default.
- W4247008721 hasConcept C104317684 @default.
- W4247008721 hasConcept C121608353 @default.
- W4247008721 hasConcept C126322002 @default.
- W4247008721 hasConcept C135763542 @default.
- W4247008721 hasConcept C143998085 @default.
- W4247008721 hasConcept C156957248 @default.
- W4247008721 hasConcept C187960798 @default.
- W4247008721 hasConcept C2908647359 @default.
- W4247008721 hasConcept C2992519594 @default.
- W4247008721 hasConcept C44249647 @default.
- W4247008721 hasConcept C530470458 @default.
- W4247008721 hasConcept C54355233 @default.
- W4247008721 hasConcept C60644358 @default.
- W4247008721 hasConcept C71924100 @default.
- W4247008721 hasConcept C76252995 @default.
- W4247008721 hasConcept C86803240 @default.
- W4247008721 hasConcept C95190672 @default.
- W4247008721 hasConcept C99454951 @default.
- W4247008721 hasConceptScore W4247008721C104317684 @default.
- W4247008721 hasConceptScore W4247008721C121608353 @default.
- W4247008721 hasConceptScore W4247008721C126322002 @default.
- W4247008721 hasConceptScore W4247008721C135763542 @default.
- W4247008721 hasConceptScore W4247008721C143998085 @default.
- W4247008721 hasConceptScore W4247008721C156957248 @default.
- W4247008721 hasConceptScore W4247008721C187960798 @default.
- W4247008721 hasConceptScore W4247008721C2908647359 @default.
- W4247008721 hasConceptScore W4247008721C2992519594 @default.
- W4247008721 hasConceptScore W4247008721C44249647 @default.
- W4247008721 hasConceptScore W4247008721C530470458 @default.
- W4247008721 hasConceptScore W4247008721C54355233 @default.
- W4247008721 hasConceptScore W4247008721C60644358 @default.
- W4247008721 hasConceptScore W4247008721C71924100 @default.
- W4247008721 hasConceptScore W4247008721C76252995 @default.
- W4247008721 hasConceptScore W4247008721C86803240 @default.
- W4247008721 hasConceptScore W4247008721C95190672 @default.
- W4247008721 hasConceptScore W4247008721C99454951 @default.
- W4247008721 hasLocation W42470087211 @default.
- W4247008721 hasLocation W42470087212 @default.
- W4247008721 hasOpenAccess W4247008721 @default.
- W4247008721 hasPrimaryLocation W42470087211 @default.
- W4247008721 hasRelatedWork W1970292265 @default.
- W4247008721 hasRelatedWork W1984235851 @default.
- W4247008721 hasRelatedWork W1993313182 @default.
- W4247008721 hasRelatedWork W2082392604 @default.
- W4247008721 hasRelatedWork W2103590513 @default.
- W4247008721 hasRelatedWork W2146282510 @default.
- W4247008721 hasRelatedWork W2159313323 @default.
- W4247008721 hasRelatedWork W2346352115 @default.
- W4247008721 hasRelatedWork W2366956643 @default.
- W4247008721 hasRelatedWork W2411114647 @default.
- W4247008721 isParatext "false" @default.
- W4247008721 isRetracted "false" @default.
- W4247008721 workType "article" @default.