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- W4247020107 abstract "Terpenoids are a class of secondary metabolites with immense variety of structures and biological activity. They are divided into some groups including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids and tetraterpenoids. Among them, there are some compounds with interesting anticancer activity capable for use in clinical or pre-clinical administration like D-limonene, perilyll alcohol and salvicine, as well as drugs derived from parthenolide, thapsigargin and artemisinin. Off-target effects, low bioavailability and adverse effects of some terpenoids like parthenolide derivatives make them unsuitable for clinical application. However, they can play a role as lead compounds for the development of semi-synthetic molecules, in which specificity and pharmacokinetic parameters would be improved. In addition, some of these compounds such as salvicine, triterpenoids and carotenoids have been able to overcome multi drug resistance by inhibition of p-glycoprotein overexpression in cancer cells demonstrating them as the proper candidate for co-administration with chemotherapy agents. Moreover, combination of these compounds with anticancer drugs may enhance the efficacy and decrease adverse effects of both drug and terpenoids." @default.
- W4247020107 created "2022-05-12" @default.
- W4247020107 creator A5068824836 @default.
- W4247020107 date "2014-12-17" @default.
- W4247020107 modified "2023-09-28" @default.
- W4247020107 title "Anticancer Terpenoids" @default.
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- W4247020107 doi "https://doi.org/10.1007/978-3-319-14027-8_5" @default.
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