Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247024832> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4247024832 endingPage "7" @default.
- W4247024832 startingPage "1" @default.
- W4247024832 abstract "Chagas' myocardiopathy, caused by the intracellular protozoan Trypanosoma cruzi, is characterized by microvascular alterations, heart failure and arrhythmias. Ischemia and arrythmogenesis have been attributed to proteins shed by the parasite, although this has not been fully demonstrated. The aim of the present investigation was to study the effect of substances shed by T. cruzi on ischemia/reperfusion-induced arrhythmias. We performed a triple ischemia-reperfusion (I/R) protocol whereby the isolated beating rat hearts were perfused with either Vero-control or Vero T. cruzi-infected conditioned medium during the different stages of ischemia and subsequently reperfused with Tyrode's solution. ECG and heart rate were recorded during the entire experiment. We observed that triple I/R-induced bradycardia was associated with the generation of auricular-ventricular blockade during ischemia and non-sustained nodal and ventricular tachycardia during reperfusion. Interestingly, perfusion with Vero-infected medium produced a delay in the reperfusion-induced recovery of heart rate, increased the frequency of tachycardic events and induced ventricular fibrillation. These results suggest that the presence of parasite-shed substances in conditioned media enhances the arrhythmogenic effects that occur during the I/R protocol." @default.
- W4247024832 created "2022-05-12" @default.
- W4247024832 creator A5022724072 @default.
- W4247024832 creator A5026646309 @default.
- W4247024832 creator A5029656105 @default.
- W4247024832 creator A5052337067 @default.
- W4247024832 creator A5071799980 @default.
- W4247024832 date "2013-01-11" @default.
- W4247024832 modified "2023-09-30" @default.
- W4247024832 title "Induction of chagasic-like arrhythmias in the isolated beating hearts of healthy rats perfused with Trypanosoma cruzi-conditioned medium" @default.
- W4247024832 doi "https://doi.org/10.1590/s0100-879x2013005002409" @default.
- W4247024832 hasPublicationYear "2013" @default.
- W4247024832 type Work @default.
- W4247024832 citedByCount "0" @default.
- W4247024832 crossrefType "journal-article" @default.
- W4247024832 hasAuthorship W4247024832A5022724072 @default.
- W4247024832 hasAuthorship W4247024832A5026646309 @default.
- W4247024832 hasAuthorship W4247024832A5029656105 @default.
- W4247024832 hasAuthorship W4247024832A5052337067 @default.
- W4247024832 hasAuthorship W4247024832A5071799980 @default.
- W4247024832 hasBestOaLocation W42470248321 @default.
- W4247024832 hasConcept C112418997 @default.
- W4247024832 hasConcept C126322002 @default.
- W4247024832 hasConcept C136764020 @default.
- W4247024832 hasConcept C146957229 @default.
- W4247024832 hasConcept C164705383 @default.
- W4247024832 hasConcept C170493617 @default.
- W4247024832 hasConcept C203014093 @default.
- W4247024832 hasConcept C2522874641 @default.
- W4247024832 hasConcept C2776331378 @default.
- W4247024832 hasConcept C2777356233 @default.
- W4247024832 hasConcept C2777495988 @default.
- W4247024832 hasConcept C2777625466 @default.
- W4247024832 hasConcept C2777953023 @default.
- W4247024832 hasConcept C2778468042 @default.
- W4247024832 hasConcept C2779161974 @default.
- W4247024832 hasConcept C2781005686 @default.
- W4247024832 hasConcept C41008148 @default.
- W4247024832 hasConcept C42219234 @default.
- W4247024832 hasConcept C541997718 @default.
- W4247024832 hasConcept C71924100 @default.
- W4247024832 hasConcept C71928629 @default.
- W4247024832 hasConcept C84393581 @default.
- W4247024832 hasConcept C89138240 @default.
- W4247024832 hasConcept C98274493 @default.
- W4247024832 hasConceptScore W4247024832C112418997 @default.
- W4247024832 hasConceptScore W4247024832C126322002 @default.
- W4247024832 hasConceptScore W4247024832C136764020 @default.
- W4247024832 hasConceptScore W4247024832C146957229 @default.
- W4247024832 hasConceptScore W4247024832C164705383 @default.
- W4247024832 hasConceptScore W4247024832C170493617 @default.
- W4247024832 hasConceptScore W4247024832C203014093 @default.
- W4247024832 hasConceptScore W4247024832C2522874641 @default.
- W4247024832 hasConceptScore W4247024832C2776331378 @default.
- W4247024832 hasConceptScore W4247024832C2777356233 @default.
- W4247024832 hasConceptScore W4247024832C2777495988 @default.
- W4247024832 hasConceptScore W4247024832C2777625466 @default.
- W4247024832 hasConceptScore W4247024832C2777953023 @default.
- W4247024832 hasConceptScore W4247024832C2778468042 @default.
- W4247024832 hasConceptScore W4247024832C2779161974 @default.
- W4247024832 hasConceptScore W4247024832C2781005686 @default.
- W4247024832 hasConceptScore W4247024832C41008148 @default.
- W4247024832 hasConceptScore W4247024832C42219234 @default.
- W4247024832 hasConceptScore W4247024832C541997718 @default.
- W4247024832 hasConceptScore W4247024832C71924100 @default.
- W4247024832 hasConceptScore W4247024832C71928629 @default.
- W4247024832 hasConceptScore W4247024832C84393581 @default.
- W4247024832 hasConceptScore W4247024832C89138240 @default.
- W4247024832 hasConceptScore W4247024832C98274493 @default.
- W4247024832 hasIssue "ahead" @default.
- W4247024832 hasLocation W42470248321 @default.
- W4247024832 hasLocation W42470248322 @default.
- W4247024832 hasOpenAccess W4247024832 @default.
- W4247024832 hasPrimaryLocation W42470248321 @default.
- W4247024832 hasRelatedWork W10158374 @default.
- W4247024832 hasRelatedWork W10807965 @default.
- W4247024832 hasRelatedWork W11112992 @default.
- W4247024832 hasRelatedWork W12105763 @default.
- W4247024832 hasRelatedWork W16352440 @default.
- W4247024832 hasRelatedWork W1718396 @default.
- W4247024832 hasRelatedWork W21871051 @default.
- W4247024832 hasRelatedWork W2725302 @default.
- W4247024832 hasRelatedWork W7767809 @default.
- W4247024832 hasRelatedWork W22981693 @default.
- W4247024832 isParatext "false" @default.
- W4247024832 isRetracted "false" @default.
- W4247024832 workType "article" @default.