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- W4247048072 abstract "Abstract Background: The role of Wilms tumor 1 ( WT1 ) mutations remains controversial for patients with acute myeloid leukemia (AML) with regard to the prognostic impact. Here, we aimed to determine the clinical implication of WT1 mutations in a large cohort of pediatric AML. Methods: The clinical data of 870 pediatric patients with AML were downloaded from the therapeutically applicable research to generate effective treatment (TARGET) dataset. We analyzed the prevalence, clinical profile and prognosis of WT1 mutations in these patients. Results: WT1 mutations were founded in 6.7% of total patients. WT1 mutations were closely associated with normal cytogenetics ( P <0.001), FMS-like tyrosine kinase 3/internal tandem duplication ( FLT3 /ITD) mutations ( P <0.001), and low complete remission induction rates ( P <0.01). Compared to patients without WT1 mutations, patients with WT1 mutations had worse 5-year event-free survival (21.7±5.5% vs 48.9±1.8%, P <0.001) and overall survival (41.4±6.6% vs 64.3±1.7%, P <0.001). Moreover, patients with both WT1 and FLT3 /ITD mutations had a dismal prognosis. Compared to chemotherapy alone, hematopoietic stem cell transplantation had a tendency to improve prognoses of WT1 -mutated patients. In multivariate analysis, WT1 mutations conferred an independent adverse impact on event-free survival (hazard ratio 1.910, P = 0.001) and overall survival (hazard ratio 1.709, P = 0.020). Conclusion: Our findings demonstrate that WT1 mutations are independent poor prognostic factors in pediatric AML." @default.
- W4247048072 created "2022-05-12" @default.
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- W4247048072 date "2020-10-26" @default.
- W4247048072 modified "2023-09-25" @default.
- W4247048072 title "Wilms Tumor 1 Mutations are Independent Poor Prognostic Factors in Pediatric Acute Myeloid Leukemia" @default.
- W4247048072 doi "https://doi.org/10.21203/rs.3.rs-95114/v1" @default.
- W4247048072 hasPublicationYear "2020" @default.
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