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- W4247119877 abstract "<h3>To the Editor.—</h3> We recently became aware of the paper by Halprin KW et al, (<i>Arch Derm</i>103:243-249, 1971), wherein the pharmacokinetics of methotrexate are described. They observed a rather short half-life (two to ten hours) for methotrexate following both oral and intramuscular administration. Based upon recent studies in our laboratory with use of tritium-labeled methotrexate, we wish to report that the plasma half-life for methotrexate in man is considerably longer than that reported. In 18 patients, the plasma disappearance of methotrexate is biphasic with the short half-life (representing drug distribution) of about one-half hour and the long plasma half-life (representing drug elimination) of 25 to 30 hours. The half-life value reported by Halprin et al most likely represents the distributive phase rather than the longer and more important half-life. In addition, we have examined the fluorometric method and find that its lower limit of sensitivity is 0.1μg/ml. Since it" @default.
- W4247119877 created "2022-05-12" @default.
- W4247119877 date "1972-05-01" @default.
- W4247119877 modified "2023-09-26" @default.
- W4247119877 doi "https://doi.org/10.1001/archderm.105.5.761" @default.
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