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- W4247129076 abstract "We examined the use of MGI-114 (6-hydroxymethyacylfulvene) for the treatment of patients with advanced colorectal carcinoma. Twenty-six patients were enrolled, with a median age of 60 years (range 41–75); 64% were male and all patients had a performance status of 0 or 1. We administered a dose of 11 mg/m2/d × 5 days every 4 weeks. With a median of two cycles (range 0–6) administered, no complete responses or partial responses were observed. Four patients had no change in disease (16%); 15 patients (57%) had progressive disease; seven patients were inevaluable (27%). Toxicity was evaluated in 25 of 26 patients. The main toxicities were hematologic, including granulocytopenia and thrombocytopenia. Neuropsychiatric adverse events included hallucination (7.7%), depression/anxiety (15.4%), and/or insomnia (19.2%). Given the lack of antitumor activity, further study of MGI-114 in colorectal cancer does not appear warranted." @default.
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- W4247129076 date "2003-04-01" @default.
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- W4247129076 title "Phase II Study of MGI-114 Administered Intravenously for 5 Days Every 28 Days to Patients With Metastatic Colorectal Cancer" @default.
- W4247129076 doi "https://doi.org/10.1097/01.coc.0000017092.65803.76" @default.
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