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- W4247130661 abstract "Adult stem cells have the capacity for self-renewal and terminal differentiation to one or more cell types. Lung stem cells include basal cells and mucus-secreting cells in the trachea, Clara cells in the bronchioles, and type II pneumocytes in the alveoli. Mesenchymal cells predominate in fetal lung development. In postnatal life the Clara cell is the most actively dividing cell in the tracheobronchial epithelium while type II pneumocytes are the progenitor cells for the alveolar epithelium. Under specific circumstances basal cells and pulmonary neuroendocrine cells may also proliferate and act as stem cells. All these putative stem cells have varied roles in normal lung repair and in disease. Mesenchymal progenitor cells and multipotential adult progenitor cells found in bone marrow differentiate into cells of endodermal, mesodermal, and ectodermal origin including lung fibroblasts. The finding of such heterogeneous stem cell populations in bone marrow and their presence in lung tissue may lead to stem cell manipulative and regenerative therapies for conditions such as idiopathic pulmonary fibrosis and cystic fibrosis transmembrane regulator gene therapy for cystic fibrosis." @default.
- W4247130661 created "2022-05-12" @default.
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- W4247130661 date "2006-01-01" @default.
- W4247130661 modified "2023-09-27" @default.
- W4247130661 title "STEM CELLS" @default.
- W4247130661 doi "https://doi.org/10.1016/b0-12-370879-6/00373-2" @default.
- W4247130661 hasPublicationYear "2006" @default.
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