Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247144611> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4247144611 abstract "Abstract Background : QT prolongation is a well-known complication when tramadol or zolpidem is ingested in large amounts acutely. However, the blood drug concentration resulting in QT prolongation or tachyarrhythmia when tramadol and zolpidem are ingested simultaneously in large amounts has not yet been reported. We report a case of acute intoxication by tramadol and zolpidem resulting in QT prolongation in a patient in whomserial blood and urine tramadol and zolpidemconcentrationswere determined. Case presentation: A 38-year-old male patient presented tothe emergency medical centrebecause ofpoisoning from 3 g of tramadol and 50 mg of zolpidemat 3 h before hisemergency department(ED) visit.During supportive treatment, he developed QT prolongation without clinical manifestations. He was discharged five days after admission without any sequelae. We measured the blood and urine concentrations of tramadol and zolpidemat various time points, which revealed ablood tramadol concentration-dependent change in QTc intervals and increasing blood tramadol concentration at 8 h after the ED visit,with a sustainedlow zolpidem concentration.Tramadol and zolpidem are metabolized by the same enzyme, cytochrome P450 3A4.Therefore, competitive inhibition bya P450 3A4isoenzyme may lead to increases indrugtoxicity. The QT interval in patients acutely intoxicated bytramadol should be evaluated carefully, particularlywhen tramadol is co-ingested with other drugs. Conclusions: Considering the half-life of tramadolor zolpidem and potential for continued absorption of drugs remaining in the gastrointestinal tract, it is necessary to observe patients viacardiac monitoring for more than 36 hafteracute intoxication.The blood concentration of tramadol may increaseand result in QT prolongationeven afterappropriate initial treatment." @default.
- W4247144611 created "2022-05-12" @default.
- W4247144611 creator A5002204988 @default.
- W4247144611 creator A5016864897 @default.
- W4247144611 creator A5018787967 @default.
- W4247144611 creator A5018887508 @default.
- W4247144611 creator A5019727419 @default.
- W4247144611 creator A5024398480 @default.
- W4247144611 creator A5035135039 @default.
- W4247144611 creator A5071650527 @default.
- W4247144611 creator A5075876055 @default.
- W4247144611 creator A5085694226 @default.
- W4247144611 date "2020-06-19" @default.
- W4247144611 modified "2023-09-27" @default.
- W4247144611 title "Serial Blood and Urine Drug Concentration Measurement in a Patient Withacute Intoxication Bytramadoland Zolpidem Resulting in Qt Prolongation: Case Report" @default.
- W4247144611 doi "https://doi.org/10.21203/rs.3.rs-36399/v1" @default.
- W4247144611 hasPublicationYear "2020" @default.
- W4247144611 type Work @default.
- W4247144611 citedByCount "0" @default.
- W4247144611 crossrefType "posted-content" @default.
- W4247144611 hasAuthorship W4247144611A5002204988 @default.
- W4247144611 hasAuthorship W4247144611A5016864897 @default.
- W4247144611 hasAuthorship W4247144611A5018787967 @default.
- W4247144611 hasAuthorship W4247144611A5018887508 @default.
- W4247144611 hasAuthorship W4247144611A5019727419 @default.
- W4247144611 hasAuthorship W4247144611A5024398480 @default.
- W4247144611 hasAuthorship W4247144611A5035135039 @default.
- W4247144611 hasAuthorship W4247144611A5071650527 @default.
- W4247144611 hasAuthorship W4247144611A5075876055 @default.
- W4247144611 hasAuthorship W4247144611A5085694226 @default.
- W4247144611 hasBestOaLocation W42471446111 @default.
- W4247144611 hasConcept C118441451 @default.
- W4247144611 hasConcept C126322002 @default.
- W4247144611 hasConcept C2777123777 @default.
- W4247144611 hasConcept C2779777798 @default.
- W4247144611 hasConcept C2780026642 @default.
- W4247144611 hasConcept C2780820201 @default.
- W4247144611 hasConcept C2781210498 @default.
- W4247144611 hasConcept C42219234 @default.
- W4247144611 hasConcept C71924100 @default.
- W4247144611 hasConcept C98274493 @default.
- W4247144611 hasConceptScore W4247144611C118441451 @default.
- W4247144611 hasConceptScore W4247144611C126322002 @default.
- W4247144611 hasConceptScore W4247144611C2777123777 @default.
- W4247144611 hasConceptScore W4247144611C2779777798 @default.
- W4247144611 hasConceptScore W4247144611C2780026642 @default.
- W4247144611 hasConceptScore W4247144611C2780820201 @default.
- W4247144611 hasConceptScore W4247144611C2781210498 @default.
- W4247144611 hasConceptScore W4247144611C42219234 @default.
- W4247144611 hasConceptScore W4247144611C71924100 @default.
- W4247144611 hasConceptScore W4247144611C98274493 @default.
- W4247144611 hasLocation W42471446111 @default.
- W4247144611 hasOpenAccess W4247144611 @default.
- W4247144611 hasPrimaryLocation W42471446111 @default.
- W4247144611 hasRelatedWork W10330520 @default.
- W4247144611 hasRelatedWork W1233682 @default.
- W4247144611 hasRelatedWork W1409955 @default.
- W4247144611 hasRelatedWork W14172853 @default.
- W4247144611 hasRelatedWork W1971001 @default.
- W4247144611 hasRelatedWork W20321379 @default.
- W4247144611 hasRelatedWork W2248153 @default.
- W4247144611 hasRelatedWork W5197031 @default.
- W4247144611 hasRelatedWork W5348209 @default.
- W4247144611 hasRelatedWork W9964867 @default.
- W4247144611 isParatext "false" @default.
- W4247144611 isRetracted "false" @default.
- W4247144611 workType "article" @default.