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- W4247152065 abstract "Abstract Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. Methods We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99m Tc-hydroxymethylene diphosphonate or 99m Tc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using GI-BONE software. Quantitative parameters, maximum SUV (SUV max ), peak SUV (SUV peak ), and mean SUV (SUV mean ) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. Results The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUV max control ratio (12.13 ± 4.95/6.44 ± 4.71), SUV peak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUV mean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23). Conclusions SUV max , peak , mean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting." @default.
- W4247152065 created "2022-05-12" @default.
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- W4247152065 date "2020-12-18" @default.
- W4247152065 modified "2023-09-28" @default.
- W4247152065 title "Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion" @default.
- W4247152065 doi "https://doi.org/10.21203/rs.3.rs-129839/v1" @default.
- W4247152065 hasPublicationYear "2020" @default.
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