Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247155549> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4247155549 endingPage "196" @default.
- W4247155549 startingPage "190" @default.
- W4247155549 abstract "The physiology of feeding ammonium sulphate in erythromycin biosynthesis phase of Saccharopolyspora erythraea on the regulation of erythromycin A (Er-A) biosynthesis was investigated in 50 L fermenter. At an optimal feeding ammonium sulphate rate of 0.03 g/L per h, the maximal Er-A production was 8281 U/mL at 174 h of growth, which was increased by 26.3% in comparison with the control (6557 U/mL at 173 h). Changes in cell metabolic response of actinomycete were observed, i.e. there was a drastic increase in the level of carbon dioxide evolution rate and oxygen consumption. Assays of the key enzyme activities and organic acids of S. erythraea and amino acids in culture broth revealed that cell metabolism was enhanced by ammonium assimilation, which might depend on the glutamate transamination pathway. The enhancement of cell metabolism induced an increase of the pool of TCA cycle and the metabolic flux of erythromycin biosynthesis. In general, ammonium assimilation in the erythromycin biosynthesis phase of S. erythraea exerted a significant impact on the carbon metabolism and formation of precursors of the process for dramatic regulation of secondary metabolites biosynthesis." @default.
- W4247155549 created "2022-05-12" @default.
- W4247155549 creator A5013881432 @default.
- W4247155549 creator A5027354884 @default.
- W4247155549 creator A5038035706 @default.
- W4247155549 creator A5038071774 @default.
- W4247155549 creator A5078319945 @default.
- W4247155549 creator A5078438135 @default.
- W4247155549 creator A5084039608 @default.
- W4247155549 date "2013-01-01" @default.
- W4247155549 modified "2023-10-04" @default.
- W4247155549 title "Biochemical Parameters ofSaccharopolyspora erythraeaduring Feeding Ammonium Sulphate in Erythromycin Biosynthesis Phase" @default.
- W4247155549 doi "https://doi.org/10.7868/s0555109913020189" @default.
- W4247155549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23795479" @default.
- W4247155549 hasPublicationYear "2013" @default.
- W4247155549 type Work @default.
- W4247155549 citedByCount "0" @default.
- W4247155549 crossrefType "journal-article" @default.
- W4247155549 hasAuthorship W4247155549A5013881432 @default.
- W4247155549 hasAuthorship W4247155549A5027354884 @default.
- W4247155549 hasAuthorship W4247155549A5038035706 @default.
- W4247155549 hasAuthorship W4247155549A5038071774 @default.
- W4247155549 hasAuthorship W4247155549A5078319945 @default.
- W4247155549 hasAuthorship W4247155549A5078438135 @default.
- W4247155549 hasAuthorship W4247155549A5084039608 @default.
- W4247155549 hasConcept C100544194 @default.
- W4247155549 hasConcept C138885662 @default.
- W4247155549 hasConcept C178790620 @default.
- W4247155549 hasConcept C181199279 @default.
- W4247155549 hasConcept C185592680 @default.
- W4247155549 hasConcept C192989942 @default.
- W4247155549 hasConcept C2779870022 @default.
- W4247155549 hasConcept C2780206985 @default.
- W4247155549 hasConcept C41895202 @default.
- W4247155549 hasConcept C501593827 @default.
- W4247155549 hasConcept C515207424 @default.
- W4247155549 hasConcept C553450214 @default.
- W4247155549 hasConcept C55493867 @default.
- W4247155549 hasConcept C62231903 @default.
- W4247155549 hasConcept C68709404 @default.
- W4247155549 hasConcept C68793091 @default.
- W4247155549 hasConcept C73401843 @default.
- W4247155549 hasConcept C75649859 @default.
- W4247155549 hasConcept C86803240 @default.
- W4247155549 hasConceptScore W4247155549C100544194 @default.
- W4247155549 hasConceptScore W4247155549C138885662 @default.
- W4247155549 hasConceptScore W4247155549C178790620 @default.
- W4247155549 hasConceptScore W4247155549C181199279 @default.
- W4247155549 hasConceptScore W4247155549C185592680 @default.
- W4247155549 hasConceptScore W4247155549C192989942 @default.
- W4247155549 hasConceptScore W4247155549C2779870022 @default.
- W4247155549 hasConceptScore W4247155549C2780206985 @default.
- W4247155549 hasConceptScore W4247155549C41895202 @default.
- W4247155549 hasConceptScore W4247155549C501593827 @default.
- W4247155549 hasConceptScore W4247155549C515207424 @default.
- W4247155549 hasConceptScore W4247155549C553450214 @default.
- W4247155549 hasConceptScore W4247155549C55493867 @default.
- W4247155549 hasConceptScore W4247155549C62231903 @default.
- W4247155549 hasConceptScore W4247155549C68709404 @default.
- W4247155549 hasConceptScore W4247155549C68793091 @default.
- W4247155549 hasConceptScore W4247155549C73401843 @default.
- W4247155549 hasConceptScore W4247155549C75649859 @default.
- W4247155549 hasConceptScore W4247155549C86803240 @default.
- W4247155549 hasIssue "2" @default.
- W4247155549 hasLocation W42471555491 @default.
- W4247155549 hasLocation W42471555492 @default.
- W4247155549 hasOpenAccess W4247155549 @default.
- W4247155549 hasPrimaryLocation W42471555491 @default.
- W4247155549 hasRelatedWork W1026634013 @default.
- W4247155549 hasRelatedWork W1581350964 @default.
- W4247155549 hasRelatedWork W2041074211 @default.
- W4247155549 hasRelatedWork W2059874632 @default.
- W4247155549 hasRelatedWork W2123346024 @default.
- W4247155549 hasRelatedWork W2331594392 @default.
- W4247155549 hasRelatedWork W2347644258 @default.
- W4247155549 hasRelatedWork W29488552 @default.
- W4247155549 hasRelatedWork W4247155549 @default.
- W4247155549 hasRelatedWork W64474836 @default.
- W4247155549 hasVolume "49" @default.
- W4247155549 isParatext "false" @default.
- W4247155549 isRetracted "false" @default.
- W4247155549 workType "article" @default.