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- W4247164064 abstract "Synthesis of 2,4-diamino-5-cyano-6-{[(diisopropoxyphosphoryl)methoxy]ethoxy}pyrimidine was based on the formation of the pyrimidine ring by cyclization followed by modification of the side chain by alkylation. The 5-cyano group was also transformed to a 5-formyl and 5-hydroxymethyl group by reduction. As a side product an unexpected dimer was formed. Resulting compounds were converted to the free phosphonic acids by treatment with bromotrimethylsilane followed by hydrolysis. The 5-cyano and 5-formyl derivatives showed pronounced antiretroviral activity, comparable to that of the reference drugs adefovir and tenofovir." @default.
- W4247164064 created "2022-05-12" @default.
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- W4247164064 date "2004-06-01" @default.
- W4247164064 modified "2023-10-17" @default.
- W4247164064 title "Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-62-(phosphonomethoxy)ethoxy9pyrimidine and related compounds" @default.
- W4247164064 doi "https://doi.org/10.1016/s0968-0896(04)00278-0" @default.
- W4247164064 hasPublicationYear "2004" @default.
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