Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247168522> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4247168522 abstract "The Alzheimer’s disease (AD) therapeutic research is yielding large number of potent molecules. The nanoparticle-based therapeutics against the protein aggregation in AD is also taking a lead especially with amyloid beta as a primary target. In this work, we have screened for first time, the protein capped (PC) metal nanoparticles for their potency in inhibiting Tau aggregation in vitro. We present a novel function of PC-CdS nanoparticles as a potent Tau aggregation inhibitor by fluorescence spectrometry, SDS-PAGE and Electron microscopy. We demonstrate that the biologically synthesized PC-metal nanoparticles, iron oxide and cadmium sulphide do not affect the viability of neuroblastoma cells. Moreover, PC-CdS nanoparticles show dual property of inhibition as well as disaggregation of Tau. Thus, the nanoparticles can take a lead as potent Tau aggregation inhibitors and can be modified for specific drug delivery due to very small size. This current work presents unprecedented strategy to design anti-Tau aggregation drugs, which provides interesting insights to understand the role of biological nanostructures in Alzheimer’s disease." @default.
- W4247168522 created "2022-05-12" @default.
- W4247168522 creator A5034873753 @default.
- W4247168522 creator A5080297743 @default.
- W4247168522 date "2019-05-31" @default.
- W4247168522 modified "2023-09-28" @default.
- W4247168522 title "Protein Capped Metal Nanoparticles Inhibits Tau Aggregation in Alzheimer’s Disease" @default.
- W4247168522 doi "https://doi.org/10.26434/chemrxiv.8208026" @default.
- W4247168522 hasPublicationYear "2019" @default.
- W4247168522 type Work @default.
- W4247168522 citedByCount "0" @default.
- W4247168522 crossrefType "posted-content" @default.
- W4247168522 hasAuthorship W4247168522A5034873753 @default.
- W4247168522 hasAuthorship W4247168522A5080297743 @default.
- W4247168522 hasConcept C12554922 @default.
- W4247168522 hasConcept C136238340 @default.
- W4247168522 hasConcept C142724271 @default.
- W4247168522 hasConcept C155672457 @default.
- W4247168522 hasConcept C161624437 @default.
- W4247168522 hasConcept C171250308 @default.
- W4247168522 hasConcept C178790620 @default.
- W4247168522 hasConcept C185592680 @default.
- W4247168522 hasConcept C192562407 @default.
- W4247168522 hasConcept C202751555 @default.
- W4247168522 hasConcept C2776156579 @default.
- W4247168522 hasConcept C2778670691 @default.
- W4247168522 hasConcept C2779134260 @default.
- W4247168522 hasConcept C2779281246 @default.
- W4247168522 hasConcept C2779820397 @default.
- W4247168522 hasConcept C502032728 @default.
- W4247168522 hasConcept C55493867 @default.
- W4247168522 hasConcept C71924100 @default.
- W4247168522 hasConcept C86803240 @default.
- W4247168522 hasConceptScore W4247168522C12554922 @default.
- W4247168522 hasConceptScore W4247168522C136238340 @default.
- W4247168522 hasConceptScore W4247168522C142724271 @default.
- W4247168522 hasConceptScore W4247168522C155672457 @default.
- W4247168522 hasConceptScore W4247168522C161624437 @default.
- W4247168522 hasConceptScore W4247168522C171250308 @default.
- W4247168522 hasConceptScore W4247168522C178790620 @default.
- W4247168522 hasConceptScore W4247168522C185592680 @default.
- W4247168522 hasConceptScore W4247168522C192562407 @default.
- W4247168522 hasConceptScore W4247168522C202751555 @default.
- W4247168522 hasConceptScore W4247168522C2776156579 @default.
- W4247168522 hasConceptScore W4247168522C2778670691 @default.
- W4247168522 hasConceptScore W4247168522C2779134260 @default.
- W4247168522 hasConceptScore W4247168522C2779281246 @default.
- W4247168522 hasConceptScore W4247168522C2779820397 @default.
- W4247168522 hasConceptScore W4247168522C502032728 @default.
- W4247168522 hasConceptScore W4247168522C55493867 @default.
- W4247168522 hasConceptScore W4247168522C71924100 @default.
- W4247168522 hasConceptScore W4247168522C86803240 @default.
- W4247168522 hasLocation W42471685221 @default.
- W4247168522 hasOpenAccess W4247168522 @default.
- W4247168522 hasPrimaryLocation W42471685221 @default.
- W4247168522 hasRelatedWork W10946511 @default.
- W4247168522 hasRelatedWork W11361684 @default.
- W4247168522 hasRelatedWork W14052319 @default.
- W4247168522 hasRelatedWork W19178780 @default.
- W4247168522 hasRelatedWork W24297654 @default.
- W4247168522 hasRelatedWork W2844834 @default.
- W4247168522 hasRelatedWork W3158660 @default.
- W4247168522 hasRelatedWork W34101472 @default.
- W4247168522 hasRelatedWork W46402581 @default.
- W4247168522 hasRelatedWork W5191796 @default.
- W4247168522 isParatext "false" @default.
- W4247168522 isRetracted "false" @default.
- W4247168522 workType "article" @default.