Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247173651> ?p ?o ?g. }
- W4247173651 endingPage "245" @default.
- W4247173651 startingPage "232" @default.
- W4247173651 abstract "This review focuses on three areas of interest with respect to the treatment of stage II and III colon and rectal cancer, including (1) tailoring adjuvant therapy for the geriatric population, (2) the controversy as to the optimal adjuvant therapy strategy for patients with locoregional rectal cancer and for patients with colorectal resectable metastatic disease, and (3) discussion of the microenvironment, molecular profiling, and the future of adjuvant therapy. It has become evident that age is the strongest predictive factor for receipt of adjuvant chemotherapy, duration of treatment, and risk of treatment-related toxicity. Although incorporating adjuvant chemotherapy for patients who have received neoadjuvant chemoradiation and surgery would appear to be a reasonable strategy to improve survivorship as an extrapolation from stage III colon cancer adjuvant trials, attempts at defining the optimal rectal cancer population that would benefit from adjuvant therapy remain elusive. Similarly, the role of adjuvant chemotherapy for patients after resection of metastatic colorectal cancer has not been clearly defined because of very limited data to provide guidance. An understanding of the biologic hallmarks and drivers of metastatic spread as well as the micrometastatic environment is expected to translate into therapeutic strategies tailored to select patients. The identification of actionable targets in mesenchymal tumors is of major interest." @default.
- W4247173651 created "2022-05-12" @default.
- W4247173651 creator A5029706633 @default.
- W4247173651 creator A5053848207 @default.
- W4247173651 creator A5087015760 @default.
- W4247173651 date "2017-05-01" @default.
- W4247173651 modified "2023-10-01" @default.
- W4247173651 title "Personalizing Adjuvant Therapy for Stage II/III Colorectal Cancer" @default.
- W4247173651 cites W1481972425 @default.
- W4247173651 cites W1482645140 @default.
- W4247173651 cites W1533165193 @default.
- W4247173651 cites W1561721283 @default.
- W4247173651 cites W1602303465 @default.
- W4247173651 cites W1899127110 @default.
- W4247173651 cites W1907263648 @default.
- W4247173651 cites W1923115269 @default.
- W4247173651 cites W1934094702 @default.
- W4247173651 cites W1944391634 @default.
- W4247173651 cites W1960485012 @default.
- W4247173651 cites W1968835926 @default.
- W4247173651 cites W1975411191 @default.
- W4247173651 cites W1997617471 @default.
- W4247173651 cites W1999297146 @default.
- W4247173651 cites W2003589572 @default.
- W4247173651 cites W2017654486 @default.
- W4247173651 cites W2020590757 @default.
- W4247173651 cites W2037900813 @default.
- W4247173651 cites W2038143310 @default.
- W4247173651 cites W2055624262 @default.
- W4247173651 cites W2056486617 @default.
- W4247173651 cites W2065139070 @default.
- W4247173651 cites W2076997626 @default.
- W4247173651 cites W2080169666 @default.
- W4247173651 cites W2084336841 @default.
- W4247173651 cites W2093679650 @default.
- W4247173651 cites W2098916599 @default.
- W4247173651 cites W2099571006 @default.
- W4247173651 cites W2100241851 @default.
- W4247173651 cites W2100258195 @default.
- W4247173651 cites W2100530362 @default.
- W4247173651 cites W2108822192 @default.
- W4247173651 cites W2111807726 @default.
- W4247173651 cites W2113029107 @default.
- W4247173651 cites W2113243295 @default.
- W4247173651 cites W2113344831 @default.
- W4247173651 cites W2114841681 @default.
- W4247173651 cites W2120615411 @default.
- W4247173651 cites W2121489550 @default.
- W4247173651 cites W2121700962 @default.
- W4247173651 cites W2121708973 @default.
- W4247173651 cites W2122117926 @default.
- W4247173651 cites W2122136304 @default.
- W4247173651 cites W2122262640 @default.
- W4247173651 cites W2123377696 @default.
- W4247173651 cites W2125373402 @default.
- W4247173651 cites W2125452425 @default.
- W4247173651 cites W2125513842 @default.
- W4247173651 cites W2126838184 @default.
- W4247173651 cites W2131072420 @default.
- W4247173651 cites W2134268158 @default.
- W4247173651 cites W2137468698 @default.
- W4247173651 cites W2138146547 @default.
- W4247173651 cites W2138309253 @default.
- W4247173651 cites W2138446143 @default.
- W4247173651 cites W2138985803 @default.
- W4247173651 cites W2140033791 @default.
- W4247173651 cites W2142821435 @default.
- W4247173651 cites W2142831070 @default.
- W4247173651 cites W2143703332 @default.
- W4247173651 cites W2144326782 @default.
- W4247173651 cites W2145131986 @default.
- W4247173651 cites W2146161922 @default.
- W4247173651 cites W2146894502 @default.
- W4247173651 cites W2147790392 @default.
- W4247173651 cites W2153294383 @default.
- W4247173651 cites W2158975681 @default.
- W4247173651 cites W2163145856 @default.
- W4247173651 cites W2163549507 @default.
- W4247173651 cites W2167600867 @default.
- W4247173651 cites W2168323176 @default.
- W4247173651 cites W2168600267 @default.
- W4247173651 cites W2168680994 @default.
- W4247173651 cites W2169710807 @default.
- W4247173651 cites W2169925647 @default.
- W4247173651 cites W2171232394 @default.
- W4247173651 cites W2185089657 @default.
- W4247173651 cites W2275337389 @default.
- W4247173651 cites W2297171155 @default.
- W4247173651 cites W2299919100 @default.
- W4247173651 cites W2310046094 @default.
- W4247173651 cites W2339723519 @default.
- W4247173651 cites W2344528818 @default.
- W4247173651 cites W2410503781 @default.
- W4247173651 cites W2413476395 @default.
- W4247173651 cites W2417402543 @default.
- W4247173651 cites W2433045063 @default.
- W4247173651 cites W2492618519 @default.
- W4247173651 cites W2496518057 @default.