Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247194041> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4247194041 endingPage "77" @default.
- W4247194041 startingPage "77" @default.
- W4247194041 abstract "We investigated the microcirculatory changes of ischemia/reperfusion injury in the diabetic rat cremaster muscle as well as the therapeutic effect of insulin. Streptozotocin-induced diabetic rats were maintained hyperglycemic for up to 8 weeks or were treated with insulin in the diabetic period. The rat cremaster muscle was prepared as an island flap and subjected to 2-h clamp ischemia followed by 1-h reperfusion. In nonischemic conditions, effective concentrations for 50% response (EC50) of serial orders of arterioles to norepinephrine were higher in diabetic muscles. Ischemia/reperfusion insult significantly decreased the EC50 of arterioles in the normal group, but not in the diabetic group. Light microscopy showed that the diabetic cremasters had more collapsed capillaries and smooth muscle-disarranged arterioles. Insulin therapy showed significant improvement in the diabetes-caused reduction of perfused capillary density, but not in the contractility of the diabetic arterioles. These results indicate that diabetes mellitus may damage the skeletal muscle microvasculature irreversibly and make it less responsive to autonomic regulation. Insulin therapy can improve capillary perfusion, but not the microvascular reactivity of diabetic muscles. © 2000 Wiley-Liss, Inc. MICROSURGERY 20:77–84 2000" @default.
- W4247194041 created "2022-05-12" @default.
- W4247194041 creator A5023488524 @default.
- W4247194041 creator A5035342455 @default.
- W4247194041 creator A5042384922 @default.
- W4247194041 creator A5086617658 @default.
- W4247194041 date "2000-01-01" @default.
- W4247194041 modified "2023-09-26" @default.
- W4247194041 title "Microcirculatory changes following reperfusion insult in diabetic rat skeletal muscles" @default.
- W4247194041 doi "https://doi.org/10.1002/(sici)1098-2752(2000)20:2<77::aid-micr6>3.3.co;2-l" @default.
- W4247194041 hasPublicationYear "2000" @default.
- W4247194041 type Work @default.
- W4247194041 citedByCount "0" @default.
- W4247194041 crossrefType "journal-article" @default.
- W4247194041 hasAuthorship W4247194041A5023488524 @default.
- W4247194041 hasAuthorship W4247194041A5035342455 @default.
- W4247194041 hasAuthorship W4247194041A5042384922 @default.
- W4247194041 hasAuthorship W4247194041A5086617658 @default.
- W4247194041 hasConcept C126322002 @default.
- W4247194041 hasConcept C12722491 @default.
- W4247194041 hasConcept C134018914 @default.
- W4247194041 hasConcept C146957229 @default.
- W4247194041 hasConcept C2776354463 @default.
- W4247194041 hasConcept C2779280383 @default.
- W4247194041 hasConcept C2779306644 @default.
- W4247194041 hasConcept C2779959927 @default.
- W4247194041 hasConcept C39133596 @default.
- W4247194041 hasConcept C541997718 @default.
- W4247194041 hasConcept C555293320 @default.
- W4247194041 hasConcept C71924100 @default.
- W4247194041 hasConceptScore W4247194041C126322002 @default.
- W4247194041 hasConceptScore W4247194041C12722491 @default.
- W4247194041 hasConceptScore W4247194041C134018914 @default.
- W4247194041 hasConceptScore W4247194041C146957229 @default.
- W4247194041 hasConceptScore W4247194041C2776354463 @default.
- W4247194041 hasConceptScore W4247194041C2779280383 @default.
- W4247194041 hasConceptScore W4247194041C2779306644 @default.
- W4247194041 hasConceptScore W4247194041C2779959927 @default.
- W4247194041 hasConceptScore W4247194041C39133596 @default.
- W4247194041 hasConceptScore W4247194041C541997718 @default.
- W4247194041 hasConceptScore W4247194041C555293320 @default.
- W4247194041 hasConceptScore W4247194041C71924100 @default.
- W4247194041 hasIssue "2" @default.
- W4247194041 hasLocation W42471940411 @default.
- W4247194041 hasOpenAccess W4247194041 @default.
- W4247194041 hasPrimaryLocation W42471940411 @default.
- W4247194041 hasRelatedWork W2003485540 @default.
- W4247194041 hasRelatedWork W2056069628 @default.
- W4247194041 hasRelatedWork W2077591403 @default.
- W4247194041 hasRelatedWork W2094002640 @default.
- W4247194041 hasRelatedWork W2112457773 @default.
- W4247194041 hasRelatedWork W2131147582 @default.
- W4247194041 hasRelatedWork W2151200778 @default.
- W4247194041 hasRelatedWork W2309978229 @default.
- W4247194041 hasRelatedWork W2434287781 @default.
- W4247194041 hasRelatedWork W4240404135 @default.
- W4247194041 hasVolume "20" @default.
- W4247194041 isParatext "false" @default.
- W4247194041 isRetracted "false" @default.
- W4247194041 workType "article" @default.