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- W4247213812 abstract "Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography (POT) with a white laser and a streak camera can measure in vivo oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb) concentration changes following physiological stimulation (familiar calls and songs). POT demonstrated sufficient sub-micromolar sensitivity to resolve the fast changes in hippocampus and auditory forebrain areas with 250 μm resolution. The time-course is composed of (i) an early 2s-long event with a significant decrease in Hb and HbO2, respectively −0.7 μMoles/L and −0.9 μMoles/L (ii) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+0.3μMoles/L) and (iii) pronounced vasodilatation events immediately following the end of the stimulus. One of the findings of our work is the direct link between the blood oxygen level-dependent (BOLD) signals previously published in birds and our results. Furthermore, the early vasoconstriction event and post-stimulus ringing seem to be more pronounced in birds than in mammals. These results in bird, a tachymetabolic vertebrate with a long lifespan, can potentially yield new insights for example in brain aging." @default.
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- W4247213812 date "2011-01-01" @default.
- W4247213812 modified "2023-09-25" @default.
- W4247213812 title "Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds" @default.
- W4247213812 doi "https://doi.org/10.1364/ecbo.2011.80880c" @default.
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