FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247223346> ?p ?o ?g. }

• W4247223346 endingPage "851" @default.
• W4247223346 startingPage "844" @default.
• W4247223346 abstract "Thyroid hormone (TH) is essential for normal development in vertebrate species. Although the mechanisms by which TH regulates developmental processes are not fully understood, intracellular T3 levels are likely to be a critical aspect of the process. Furthermore, as different tissues and organs have specific temporal patterns of development, their T3 requirements may vary widely. Differential regulation of intracellular T3 levels in peripheral tissues as a result of differences in the activities of the three iodothyronine deiodinases (D1, D2, and D3) could offer an important means of achieving coordination of T3-dependent developmental processes among tissues. To obtain evidence for this concept we have documented the levels of expression of all three types of deiodinase in 11 tissues of the fetus, the neonate, and the adult rat. In most fetal tissues, D3 was the predominant deiodinase, but it declined after birth as the activities of D1 and D2 increased. Exceptions to this pattern were skin and brown adipose tissue (BAT), in which D2 activity was highest in the fetus, and testis and thyroid in which D2 activity was higher in the neonate than in the adult. D1 was the only 5′D enzyme expressed in liver, kidney and intestine at all stages studied, and D3 was not expressed in these tissues after birth. Thyroid, pituitary, and BAT expressed either D2 or D2 plus D1, but did not express D3 at any stage studied. Cerebrum, cerebellum, ovary, testis, skin, and placenta expressed all three deiodinases. Two other points were evident. First, the maximum 5′D activity attained, and thus presumably the amount of T3 generated, in liver, kidney, intestine, thyroid, pituitary, and BAT was very much higher than that in cerebrum, cerebellum, ovary, testis, skin, and placenta. Second, in the tissues where 5′D activity was relatively low, coexpression of D3 with D1 and D2 was the general rule, suggesting the need for very tight control of intracellular T3 levels. The findings are consistent with the view that the deiodinases play a major role in achieving the intracellular T3 levels that are optimal for the development of each tissue. Additional studies are in progress to demonstrate the functional consequences of these deiodinase expression patterns." @default.
• W4247223346 created "2022-05-12" @default.
• W4247223346 creator A5005191420 @default.
• W4247223346 date "1999-02-01" @default.
• W4247223346 modified "2023-10-16" @default.
• W4247223346 title "Expression Profiles of the Three Iodothyronine Deiodinases, D1, D2, and D3, in the Developing Rat" @default.
• W4247223346 doi "https://doi.org/10.1210/en.140.2.844" @default.
• W4247223346 hasPublicationYear "1999" @default.
• W4247223346 type Work @default.
• W4247223346 citedByCount "47" @default.
• W4247223346 countsByYear W42472233462012 @default.
• W4247223346 countsByYear W42472233462013 @default.
• W4247223346 countsByYear W42472233462014 @default.
• W4247223346 countsByYear W42472233462015 @default.
• W4247223346 countsByYear W42472233462016 @default.
• W4247223346 countsByYear W42472233462017 @default.
• W4247223346 countsByYear W42472233462018 @default.
• W4247223346 crossrefType "journal-article" @default.
• W4247223346 hasAuthorship W4247223346A5005191420 @default.
• W4247223346 hasBestOaLocation W42472233461 @default.
• W4247223346 hasConcept C126322002 @default.
• W4247223346 hasConcept C134018914 @default.
• W4247223346 hasConcept C172680121 @default.
• W4247223346 hasConcept C2776515397 @default.
• W4247223346 hasConcept C2778288131 @default.
• W4247223346 hasConcept C2778417266 @default.
• W4247223346 hasConcept C2779234561 @default.
• W4247223346 hasConcept C526584372 @default.
• W4247223346 hasConcept C54355233 @default.
• W4247223346 hasConcept C71315377 @default.
• W4247223346 hasConcept C71924100 @default.
• W4247223346 hasConcept C86803240 @default.
• W4247223346 hasConceptScore W4247223346C126322002 @default.
• W4247223346 hasConceptScore W4247223346C134018914 @default.
• W4247223346 hasConceptScore W4247223346C172680121 @default.
• W4247223346 hasConceptScore W4247223346C2776515397 @default.
• W4247223346 hasConceptScore W4247223346C2778288131 @default.
• W4247223346 hasConceptScore W4247223346C2778417266 @default.
• W4247223346 hasConceptScore W4247223346C2779234561 @default.
• W4247223346 hasConceptScore W4247223346C526584372 @default.
• W4247223346 hasConceptScore W4247223346C54355233 @default.
• W4247223346 hasConceptScore W4247223346C71315377 @default.
• W4247223346 hasConceptScore W4247223346C71924100 @default.
• W4247223346 hasConceptScore W4247223346C86803240 @default.
• W4247223346 hasIssue "2" @default.
• W4247223346 hasLocation W42472233461 @default.
• W4247223346 hasOpenAccess W4247223346 @default.
• W4247223346 hasPrimaryLocation W42472233461 @default.
• W4247223346 hasRelatedWork W2005744729 @default.
• W4247223346 hasRelatedWork W2026005581 @default.
• W4247223346 hasRelatedWork W2055124061 @default.
• W4247223346 hasRelatedWork W2085166043 @default.
• W4247223346 hasRelatedWork W2155312245 @default.
• W4247223346 hasRelatedWork W2163236351 @default.
• W4247223346 hasRelatedWork W2164661085 @default.
• W4247223346 hasRelatedWork W2169697618 @default.
• W4247223346 hasRelatedWork W2375793568 @default.
• W4247223346 hasRelatedWork W4256563120 @default.
• W4247223346 hasVolume "140" @default.
• W4247223346 isParatext "false" @default.
• W4247223346 isRetracted "false" @default.
• W4247223346 workType "article" @default.