FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247236578> ?p ?o ?g. }

• W4247236578 endingPage "iii14" @default.
• W4247236578 startingPage "iii14" @default.
• W4247236578 abstract "Abstract BACKGROUND Health-related quality of life (HRQoL) is often used as an outcome in glioma research, reflecting the impact of disease and treatment on a patient’s functioning and wellbeing. Data on changes in HRQoL scores may provide important information for clinical decision-making, but different analytical methods may lead to different interpretations of the impact of treatment on HRQoL. This study aimed to examine three different methods to evaluate change in HRQoL, and to study whether these methods result in different interpretations. MATERIAL AND METHODS HRQoL and sociodemographical/clinical data from 15 randomized clinical trials were combined. Change in HRQoL scores was analyzed in three ways: (1) at the group level, comparing mean changes in scale/item scores between treatment arms over time, (2) at the patient level per scale/item by calculating the percentage of patients that deteriorated, improved or remained stable on a scale/item per scale/item, and (3) at the individual patient level combining all scales/items. RESULTS Baseline and first follow-up HRQoL data were available for 3727 patients. At the group scale/item level (method 1), only the item ‘hair loss’ showed a significant and clinically relevant change (i.e. ≥10 points) over time, whereas change scores on the other scales/items showed a statistically significant change only (all p<.001, range in change score: 0.1–6.2). Analyses on the patient level per scale (method 2) indicated that, while a large proportion of patients had stable HRQoL over time (range 27–84%), many patients deteriorated (range: 6–43%) or improved (range: 8–32%) on a specific scale/item. At the individual patient level (method 3), the majority of patients (86%) showed both deterioration and improvement, while only 1% of the patients remained stable on all scales. Clustering on clinical characteristics (WHO performance status, sex, tumor type, type of resection, newly diagnosed versus recurrent tumor and age) did not identify subgroups of patients with a specific pattern of change in their HRQoL score. CONCLUSION Different analytical methods of changes in HRQoL result in distinct interpretations of treatment effects, all of which may be relevant for clinical decision-making. Additional information about the joint impact of treatment on all outcomes, showing that most patients experience both deterioration and improvement, may help patients and physicians to make the best treatment decision." @default.
• W4247236578 created "2022-05-12" @default.
• W4247236578 creator A5010706157 @default.
• W4247236578 creator A5010791019 @default.
• W4247236578 creator A5015612720 @default.
• W4247236578 creator A5023090848 @default.
• W4247236578 creator A5027431274 @default.
• W4247236578 creator A5031777632 @default.
• W4247236578 creator A5033909956 @default.
• W4247236578 creator A5042334675 @default.
• W4247236578 creator A5053052330 @default.
• W4247236578 creator A5053255415 @default.
• W4247236578 creator A5053739570 @default.
• W4247236578 creator A5056837393 @default.
• W4247236578 creator A5066122910 @default.
• W4247236578 creator A5066290988 @default.
• W4247236578 creator A5079004439 @default.
• W4247236578 creator A5080482957 @default.
• W4247236578 creator A5082037983 @default.
• W4247236578 creator A5085405152 @default.
• W4247236578 creator A5086283695 @default.
• W4247236578 creator A5088995687 @default.
• W4247236578 date "2019-08-01" @default.
• W4247236578 modified "2023-10-01" @default.
• W4247236578 title "OS7.2 Measuring change in health-related quality of life: the added value of analysis on the individual patient level in glioma patients in clinical decision making" @default.
• W4247236578 doi "https://doi.org/10.1093/neuonc/noz126.045" @default.
• W4247236578 hasPublicationYear "2019" @default.
• W4247236578 type Work @default.
• W4247236578 citedByCount "0" @default.
• W4247236578 crossrefType "journal-article" @default.
• W4247236578 hasAuthorship W4247236578A5010706157 @default.
• W4247236578 hasAuthorship W4247236578A5010791019 @default.
• W4247236578 hasAuthorship W4247236578A5015612720 @default.
• W4247236578 hasAuthorship W4247236578A5023090848 @default.
• W4247236578 hasAuthorship W4247236578A5027431274 @default.
• W4247236578 hasAuthorship W4247236578A5031777632 @default.
• W4247236578 hasAuthorship W4247236578A5033909956 @default.
• W4247236578 hasAuthorship W4247236578A5042334675 @default.
• W4247236578 hasAuthorship W4247236578A5053052330 @default.
• W4247236578 hasAuthorship W4247236578A5053255415 @default.
• W4247236578 hasAuthorship W4247236578A5053739570 @default.
• W4247236578 hasAuthorship W4247236578A5056837393 @default.
• W4247236578 hasAuthorship W4247236578A5066122910 @default.
• W4247236578 hasAuthorship W4247236578A5066290988 @default.
• W4247236578 hasAuthorship W4247236578A5079004439 @default.
• W4247236578 hasAuthorship W4247236578A5080482957 @default.
• W4247236578 hasAuthorship W4247236578A5082037983 @default.
• W4247236578 hasAuthorship W4247236578A5085405152 @default.
• W4247236578 hasAuthorship W4247236578A5086283695 @default.
• W4247236578 hasAuthorship W4247236578A5088995687 @default.
• W4247236578 hasBestOaLocation W42472365781 @default.
• W4247236578 hasConcept C121332964 @default.
• W4247236578 hasConcept C126322002 @default.
• W4247236578 hasConcept C159110408 @default.
• W4247236578 hasConcept C1862650 @default.
• W4247236578 hasConcept C2778755073 @default.
• W4247236578 hasConcept C2779134260 @default.
• W4247236578 hasConcept C2779517570 @default.
• W4247236578 hasConcept C2779951463 @default.
• W4247236578 hasConcept C3019006561 @default.
• W4247236578 hasConcept C535046627 @default.
• W4247236578 hasConcept C62520636 @default.
• W4247236578 hasConcept C71924100 @default.
• W4247236578 hasConceptScore W4247236578C121332964 @default.
• W4247236578 hasConceptScore W4247236578C126322002 @default.
• W4247236578 hasConceptScore W4247236578C159110408 @default.
• W4247236578 hasConceptScore W4247236578C1862650 @default.
• W4247236578 hasConceptScore W4247236578C2778755073 @default.
• W4247236578 hasConceptScore W4247236578C2779134260 @default.
• W4247236578 hasConceptScore W4247236578C2779517570 @default.
• W4247236578 hasConceptScore W4247236578C2779951463 @default.
• W4247236578 hasConceptScore W4247236578C3019006561 @default.
• W4247236578 hasConceptScore W4247236578C535046627 @default.
• W4247236578 hasConceptScore W4247236578C62520636 @default.
• W4247236578 hasConceptScore W4247236578C71924100 @default.
• W4247236578 hasIssue "Supplement_3" @default.
• W4247236578 hasLocation W42472365781 @default.
• W4247236578 hasLocation W42472365782 @default.
• W4247236578 hasOpenAccess W4247236578 @default.
• W4247236578 hasPrimaryLocation W42472365781 @default.
• W4247236578 hasRelatedWork W13308443 @default.
• W4247236578 hasRelatedWork W16606038 @default.
• W4247236578 hasRelatedWork W23244233 @default.
• W4247236578 hasRelatedWork W2507423 @default.
• W4247236578 hasRelatedWork W26219120 @default.
• W4247236578 hasRelatedWork W26520443 @default.
• W4247236578 hasRelatedWork W3504634 @default.
• W4247236578 hasRelatedWork W5104596 @default.
• W4247236578 hasRelatedWork W5788072 @default.
• W4247236578 hasRelatedWork W9834130 @default.
• W4247236578 hasVolume "21" @default.
• W4247236578 isParatext "false" @default.
• W4247236578 isRetracted "false" @default.
• W4247236578 workType "article" @default.