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- W4247284951 abstract "Most functional magnetic resonance imaging (fMRI) studies of brain activity rely on hemodynamic (blood-flow) responses to transduce neural activity into magnetic resonance imaging (MRI) signal changes. Hemodynamic fMRI methods do not directly measure the firing patterns of brain cells or neurotransmitter release, however, and therefore provide little information about the biological mechanisms that underlie neural processing. To obtain noninvasive readouts that are more directly related to functionally distinct components of brain activity, it has recently become possible to use molecular imaging agents – injectable compounds that probe aspects of neural activity and can be monitored by MRI. The design and synthesis of such agents have evolved in recent years to yield a variety of compounds that enable the detection of specific proteins and small molecules involved in brain function. This chapter presents recent advances in the development of ‘molecular fMRI’ approaches to studying the brain." @default.
- W4247284951 created "2022-05-12" @default.
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- W4247284951 date "2015-01-01" @default.
- W4247284951 modified "2023-09-30" @default.
- W4247284951 title "Molecular fMRI" @default.
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- W4247284951 doi "https://doi.org/10.1016/b978-0-12-397025-1.00013-0" @default.
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