FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247292502> ?p ?o ?g. }

• W4247292502 endingPage "1059" @default.
• W4247292502 startingPage "1052" @default.
• W4247292502 abstract "Dexmedetomidine is a selective alpha(2)-agonist approved for sedation of critically ill patients. There is little information on the effects of dexmedetomidine on cerebral blood flow (CBF) or intracranial hemodynamics, despite considerable other pharmacodynamic data. We hypothesized that therapeutic doses of dexmedetomidine would decrease CBF. Therefore, nine supine volunteers, aged 24-48 yr, were infused with a 1 micro g/kg IV loading dose of dexmedetomidine, followed by an infusion of 0.2 micro g. kg(-1). h(-1) (LOW DEX) and 0.6 micro g. kg(-1). h(-1) (HIGH DEX). Hemodynamic and CBF (via positron emission tomography) measurements were determined at each experimental time point. Dexmedetomidine decreased both cardiac output and heart rate during and 30 min after drug administration. Blood pressure decreased from 12% to 16% during and after the dexmedetomidine administration. Global CBF was decreased significantly from baseline (91 mL. 100 g(-1). min(-1) [95% confidence interval, 72-114] to 64 mL. 100 g(-1). min(-1) [51-81] LOW DEX and 61 mL. 100 g(-1). min(-1) [48-76] HIGH DEX). This decrease in CBF remained constant for at least 30 min after the dexmedetomidine infusion was discontinued, despite the plasma dexmedetomidine concentration decreasing 40% during this same time period (628 pg/mL [524-732] to 380 pg/mL [253-507]).Dexmedetomidine-induced sedation decreased cerebral blood flow (CBF) by congruent with 33%, which could be due to direct alpha(2)-receptor cerebral smooth muscle vasoconstriction or to compensatory CBF changes caused by dexmedetomidine-induced decreases in the cerebral metabolic rate." @default.
• W4247292502 created "2022-05-12" @default.
• W4247292502 creator A5008737075 @default.
• W4247292502 creator A5009215031 @default.
• W4247292502 creator A5022078528 @default.
• W4247292502 creator A5028383427 @default.
• W4247292502 creator A5037079512 @default.
• W4247292502 creator A5041601065 @default.
• W4247292502 creator A5047167528 @default.
• W4247292502 creator A5054567072 @default.
• W4247292502 creator A5070404220 @default.
• W4247292502 creator A5071588829 @default.
• W4247292502 creator A5086235377 @default.
• W4247292502 date "2002-10-01" @default.
• W4247292502 modified "2023-10-05" @default.
• W4247292502 title "Dexmedetomidine-Induced Sedation in Volunteers Decreases Regional and Global Cerebral Blood Flow" @default.
• W4247292502 cites W1577997420 @default.
• W4247292502 cites W1971101248 @default.
• W4247292502 cites W1973212608 @default.
• W4247292502 cites W1984814351 @default.
• W4247292502 cites W1997264966 @default.
• W4247292502 cites W2007424914 @default.
• W4247292502 cites W2012141507 @default.
• W4247292502 cites W2033017054 @default.
• W4247292502 cites W2034557139 @default.
• W4247292502 cites W2038782045 @default.
• W4247292502 cites W2041322579 @default.
• W4247292502 cites W2045646024 @default.
• W4247292502 cites W2052347649 @default.
• W4247292502 cites W2102945855 @default.
• W4247292502 cites W2161157981 @default.
• W4247292502 cites W2263478400 @default.
• W4247292502 cites W2280727632 @default.
• W4247292502 cites W3022929210 @default.
• W4247292502 cites W3192141250 @default.
• W4247292502 cites W4214651213 @default.
• W4247292502 cites W4236949851 @default.
• W4247292502 cites W4254386266 @default.
• W4247292502 doi "https://doi.org/10.1097/00000539-200210000-00048" @default.
• W4247292502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12351293" @default.
• W4247292502 hasPublicationYear "2002" @default.
• W4247292502 type Work @default.
• W4247292502 citedByCount "36" @default.
• W4247292502 countsByYear W42472925022012 @default.
• W4247292502 countsByYear W42472925022013 @default.
• W4247292502 countsByYear W42472925022015 @default.
• W4247292502 countsByYear W42472925022016 @default.
• W4247292502 countsByYear W42472925022017 @default.
• W4247292502 countsByYear W42472925022018 @default.
• W4247292502 countsByYear W42472925022019 @default.
• W4247292502 countsByYear W42472925022020 @default.
• W4247292502 countsByYear W42472925022021 @default.
• W4247292502 countsByYear W42472925022022 @default.
• W4247292502 crossrefType "journal-article" @default.
• W4247292502 hasAuthorship W4247292502A5008737075 @default.
• W4247292502 hasAuthorship W4247292502A5009215031 @default.
• W4247292502 hasAuthorship W4247292502A5022078528 @default.
• W4247292502 hasAuthorship W4247292502A5028383427 @default.
• W4247292502 hasAuthorship W4247292502A5037079512 @default.
• W4247292502 hasAuthorship W4247292502A5041601065 @default.
• W4247292502 hasAuthorship W4247292502A5047167528 @default.
• W4247292502 hasAuthorship W4247292502A5054567072 @default.
• W4247292502 hasAuthorship W4247292502A5070404220 @default.
• W4247292502 hasAuthorship W4247292502A5071588829 @default.
• W4247292502 hasAuthorship W4247292502A5086235377 @default.
• W4247292502 hasBestOaLocation W42472925021 @default.
• W4247292502 hasConcept C126322002 @default.
• W4247292502 hasConcept C157767197 @default.
• W4247292502 hasConcept C170493617 @default.
• W4247292502 hasConcept C178853913 @default.
• W4247292502 hasConcept C2776814716 @default.
• W4247292502 hasConcept C2777953023 @default.
• W4247292502 hasConcept C2778938600 @default.
• W4247292502 hasConcept C2781302539 @default.
• W4247292502 hasConcept C35294091 @default.
• W4247292502 hasConcept C42219234 @default.
• W4247292502 hasConcept C71924100 @default.
• W4247292502 hasConcept C84393581 @default.
• W4247292502 hasConceptScore W4247292502C126322002 @default.
• W4247292502 hasConceptScore W4247292502C157767197 @default.
• W4247292502 hasConceptScore W4247292502C170493617 @default.
• W4247292502 hasConceptScore W4247292502C178853913 @default.
• W4247292502 hasConceptScore W4247292502C2776814716 @default.
• W4247292502 hasConceptScore W4247292502C2777953023 @default.
• W4247292502 hasConceptScore W4247292502C2778938600 @default.
• W4247292502 hasConceptScore W4247292502C2781302539 @default.
• W4247292502 hasConceptScore W4247292502C35294091 @default.
• W4247292502 hasConceptScore W4247292502C42219234 @default.
• W4247292502 hasConceptScore W4247292502C71924100 @default.
• W4247292502 hasConceptScore W4247292502C84393581 @default.
• W4247292502 hasIssue "4" @default.
• W4247292502 hasLocation W42472925021 @default.
• W4247292502 hasLocation W42472925022 @default.
• W4247292502 hasLocation W42472925023 @default.
• W4247292502 hasOpenAccess W4247292502 @default.
• W4247292502 hasPrimaryLocation W42472925021 @default.
• W4247292502 hasRelatedWork W2126545071 @default.
• W4247292502 hasRelatedWork W2159176145 @default.

• next