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- W4247310306 abstract "Cryptolepine, an alkaloid of Cryptolepsis sanguinolenta, reduced the response of the guinea-pig ileum to both acetylcholine and prostaglandin E2. It also reduced the twitch response of the ileum evoked by coaxial electrical stimulation. The calculated pA2 value for the crytolepine/acetylcholine interaction was 6.2. The cryptolepine/prostaglandin E2 interaction was non-competitive. Very high concentrations of the alkaloid (200 µg to 800 µg ml-1) induced a slight non-specific contraction of the ileum. The involvement of Cryptolepine in 1. direct smooth muscle contraction, 2. cholinergic nerve transmissions and 3. modification of the modulatory role of prostaglandins in cholinergic nerve transmission in guinea-pig ileum is suggested." @default.
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- W4247310306 date "1983-05-01" @default.
- W4247310306 modified "2023-09-26" @default.
- W4247310306 title "Studies on Cryptolepine" @default.
- W4247310306 doi "https://doi.org/10.1055/s-2007-969877" @default.
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