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- W4247320946 abstract "Abstract Colorectal cancer (CRC) is one of the most well-known malignancies with high prevalence and poor 5-year survival. Previous studies have demonstrated that high-fat diet (HFD) is capable of increasing the odds of developing CRC. Acrolein, an IARC group 2A carcinogen, can be formed through Maillard reaction. Also, acrolein has been shown to be produced from microbial glycerol metabolism in human gut. Consequently, humans are at risk of acrolein exposure through consumption of foods rich in fat. However, whether acrolein contributes to HFD-induced CRC remains elusive. In this study, we found that acrolein induced oncogenic transformation including faster cell cycling, proliferation, soft agar formation, sphere formation and cell migration in NIH/3T3 cells. Using xenograft tumorigenicity assays, the acrolein-transformed NIH/3T3 clone formed tumors. In addition, RAS/MAPK pathway contributing to colon tumorigenesis was activated in acrolein-transformed clones using cDNA microarray analysis with Ingenuity Pathway Analysis. Besides, acrolein-induced DNA damages (Acr-dG adducts) were higher in CRC tumor tissues compared to normal epithelial cells in CRC patients. Intriguingly, CRC patients with higher Acr-dG adducts have better prognosis. Taken together, this is the first study to demonstrate that acrolein is important in oncogenic transformation through activating RAS/MAPK signaling pathway contributing to colon tumorigenesis." @default.
- W4247320946 created "2022-05-12" @default.
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- W4247320946 date "2021-01-13" @default.
- W4247320946 modified "2023-10-18" @default.
- W4247320946 title "Acrolein Contributes to Human Colorectal Tumorigenesis Through the Activation of RAS/MAPK Pathway." @default.
- W4247320946 doi "https://doi.org/10.21203/rs.3.rs-142335/v1" @default.
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