Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247331246> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4247331246 abstract "Abstract Background The mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis. Methods To compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group. Results Univariate analysis showed that demographic characteristics, including occupation, educational level, monthly income and speaking background; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005). Conclusions We determined an association between MSD phenotype and cognitive impairment, reflected by low-level education and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD." @default.
- W4247331246 created "2022-05-12" @default.
- W4247331246 creator A5006642847 @default.
- W4247331246 creator A5008900748 @default.
- W4247331246 creator A5017163466 @default.
- W4247331246 creator A5043342429 @default.
- W4247331246 creator A5058663486 @default.
- W4247331246 creator A5060002817 @default.
- W4247331246 creator A5061456513 @default.
- W4247331246 creator A5070389056 @default.
- W4247331246 creator A5073195492 @default.
- W4247331246 date "2019-10-15" @default.
- W4247331246 modified "2023-09-27" @default.
- W4247331246 title "Attention/Memory Impairment is Correlated with Motor Speech Disorder in Parkinson’s Disease" @default.
- W4247331246 doi "https://doi.org/10.21203/rs.2.10770/v2" @default.
- W4247331246 hasPublicationYear "2019" @default.
- W4247331246 type Work @default.
- W4247331246 citedByCount "0" @default.
- W4247331246 crossrefType "posted-content" @default.
- W4247331246 hasAuthorship W4247331246A5006642847 @default.
- W4247331246 hasAuthorship W4247331246A5008900748 @default.
- W4247331246 hasAuthorship W4247331246A5017163466 @default.
- W4247331246 hasAuthorship W4247331246A5043342429 @default.
- W4247331246 hasAuthorship W4247331246A5058663486 @default.
- W4247331246 hasAuthorship W4247331246A5060002817 @default.
- W4247331246 hasAuthorship W4247331246A5061456513 @default.
- W4247331246 hasAuthorship W4247331246A5070389056 @default.
- W4247331246 hasAuthorship W4247331246A5073195492 @default.
- W4247331246 hasBestOaLocation W42473312461 @default.
- W4247331246 hasConcept C105795698 @default.
- W4247331246 hasConcept C118552586 @default.
- W4247331246 hasConcept C126322002 @default.
- W4247331246 hasConcept C151956035 @default.
- W4247331246 hasConcept C15744967 @default.
- W4247331246 hasConcept C161584116 @default.
- W4247331246 hasConcept C169900460 @default.
- W4247331246 hasConcept C199163554 @default.
- W4247331246 hasConcept C27415008 @default.
- W4247331246 hasConcept C2779134260 @default.
- W4247331246 hasConcept C2779734285 @default.
- W4247331246 hasConcept C33923547 @default.
- W4247331246 hasConcept C38180746 @default.
- W4247331246 hasConcept C548259974 @default.
- W4247331246 hasConcept C71924100 @default.
- W4247331246 hasConceptScore W4247331246C105795698 @default.
- W4247331246 hasConceptScore W4247331246C118552586 @default.
- W4247331246 hasConceptScore W4247331246C126322002 @default.
- W4247331246 hasConceptScore W4247331246C151956035 @default.
- W4247331246 hasConceptScore W4247331246C15744967 @default.
- W4247331246 hasConceptScore W4247331246C161584116 @default.
- W4247331246 hasConceptScore W4247331246C169900460 @default.
- W4247331246 hasConceptScore W4247331246C199163554 @default.
- W4247331246 hasConceptScore W4247331246C27415008 @default.
- W4247331246 hasConceptScore W4247331246C2779134260 @default.
- W4247331246 hasConceptScore W4247331246C2779734285 @default.
- W4247331246 hasConceptScore W4247331246C33923547 @default.
- W4247331246 hasConceptScore W4247331246C38180746 @default.
- W4247331246 hasConceptScore W4247331246C548259974 @default.
- W4247331246 hasConceptScore W4247331246C71924100 @default.
- W4247331246 hasLocation W42473312461 @default.
- W4247331246 hasOpenAccess W4247331246 @default.
- W4247331246 hasPrimaryLocation W42473312461 @default.
- W4247331246 hasRelatedWork W1032063 @default.
- W4247331246 hasRelatedWork W10568491 @default.
- W4247331246 hasRelatedWork W11726579 @default.
- W4247331246 hasRelatedWork W12517488 @default.
- W4247331246 hasRelatedWork W12562404 @default.
- W4247331246 hasRelatedWork W12799130 @default.
- W4247331246 hasRelatedWork W2349528 @default.
- W4247331246 hasRelatedWork W3392268 @default.
- W4247331246 hasRelatedWork W6110849 @default.
- W4247331246 hasRelatedWork W9151420 @default.
- W4247331246 isParatext "false" @default.
- W4247331246 isRetracted "false" @default.
- W4247331246 workType "article" @default.