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- W4247334464 endingPage "517" @default.
- W4247334464 startingPage "507" @default.
- W4247334464 abstract "Drug-induced prolongation of the QT interval in the electrocardiogram has been associated with life-threatening ventricular tachycardia of the Torsades de Pointes type. To prevent this risk to patients, all new drug entities must undergo thorough in vitro and preclinical in vivo testing. Because a hERG channel block is the primary reason for ventricular repolarisation, disturbances causing a QT interval prolongation, established in vitro test systems focus on the analysis of drug action on hERG channel function. More sophisticated assays study ventricular repolarisation directly with cardiac tissue preparations. In addition, in the future, novel biological models, such as stem-cell-derived cardiomyocytes and cardiac tissue slices, may allow the design of innovative assay systems to address relevant cardiac safety pharmacology parameters. In this review, established as well as innovative assays and cell models used in these assays are discussed." @default.
- W4247334464 created "2022-05-12" @default.
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- W4247334464 creator A5066393440 @default.
- W4247334464 creator A5018227114 @default.
- W4247334464 date "2007-08-01" @default.
- W4247334464 modified "2023-09-26" @default.
- W4247334464 title "New cell models and assays in cardiac safety profiling" @default.
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- W4247334464 doi "https://doi.org/10.1517/17425255.3.4.507" @default.
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