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- W4247335852 abstract "The site and mechanism of action of O2 in the peripheral microcirculation. Schematic diagram showing an extravascular sensor cell and a longitudinal section through an arteriole under low and high conditions as indicated. Oxygen-sensitive enzymes in the sensor cells (generically labelled as Oxygenase), respond to elevation in the in their environment by increasing the production of a vasoconstrictor (labelled Mediator) that acts on vascular smooth muscle cells (VSM) to produce membrane depolarization, opening of L-type Ca2+ channels and vasoconstriction. The depolarization will be conducted electrotonically along the wall of the arteriole via gap junctions to produce conducted vasoconstriction to sites distant from the initial action of the mediator. The opposite occurs when the falls from a high to a lower level. ER, endoplasmic reticulum; CysLTs, cysteinyl leukotrienes. See text for more information." @default.
- W4247335852 created "2022-05-12" @default.
- W4247335852 date "2016-09-15" @default.
- W4247335852 modified "2023-10-01" @default.
- W4247335852 doi "https://doi.org/10.1113/tjp.2016.594.issue-18" @default.
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