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- W4247343172 abstract "The Three-City Study observed a significant interaction between circulating levels of estradiol and diabetes on risk for all-cause dementia in older women, and the Women's Health Initiative Memory Study (WHIMS) found that diabetes and assignment to hormone therapy (HT) were separately associated with smaller brain volumes and poorer cognition. In addition, randomization to HT vs placebo increased the risk for cognitive impairment in older women. Here, we assessed for an interaction between assignment to HT and diabetes status on brain volumes in the WHIMS cohort. Brain imaging and cognitive data from 1,402 women from the magnetic resonance imaging substudy of the Women's Health Initiative (WHIMS-MRI) were used. All participants were part of the Women's Health Initiative study, a clinical trial where women were randomized to receive HT (0.625 mg/day conjugated equine estrogens with or without 2.5 mg/day medroxyprogesterone acetate) or placebo. For this analysis, diabetes status was determined based on self-report of treatment for diabetes or fasting plasma glucose ≥ 126 mg/dL in women where this was measured. Brain volumes were derived from T1-weighted anatomical images. Relationships were assessed using general linear models. Diabetes status, HT assignment, and their interaction were included as fixed effects to assess their relationship with brain volumes and changes in brain volumes. Women with diabetes assigned to HT had a mean [95% confidence interval] decrement of -18.6 [-29.6, -7.6] in total brain volume relative to women with diabetes assigned to placebo. For women without diabetes, this mean decrement was -0.4 [-3.8,3.0].The interaction between diabetes status and HT assignment on brain volume was significant for total brain (p=0.002), grey matter (<0.001), and hippocampal (p=0.006) volumes, but not for white matter (p=0.92) or frontal lobe (p=0.24) volumes. Differences between HT treatment and placebo groups were consistently smaller for women without diabetes. The interaction was not explained by baseline cognitive function or body mass index. Given that diabetes is known to negatively affect the brain and cognition, these findings support the theory of a healthy cell bias for estrogen action, where estrogen exposure has differential effects depending on the metabolic status of cells." @default.
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- W4247343172 date "2015-07-01" @default.
- W4247343172 modified "2023-10-02" @default.
- W4247343172 title "O3-01-01: Interactions of diabetes and postmenopausal hormone therapy on brain volumes: Whims" @default.
- W4247343172 doi "https://doi.org/10.1016/j.jalz.2015.07.236" @default.
- W4247343172 hasPublicationYear "2015" @default.
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