FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247376504> ?p ?o ?g. }

• W4247376504 endingPage "4417" @default.
• W4247376504 startingPage "4406" @default.
• W4247376504 abstract "Genetic studies in animal models of microcytic anemia and biochemical studies of transport have implicated the Nramp2gene in iron transport. Nramp2 generates two alternatively spliced mRNAs that differ at their 3′ untranslated region by the presence or absence of an iron-response element (IRE) and that encode two proteins with distinct carboxy termini. Antisera raised against Nramp2 fusion proteins containing either the carboxy or amino termini of Nramp2 and that can help distinguish between the two Nramp2 protein isoforms (IRE: isoform I; non-IRE: isoform II) were generated. These antibodies were used to identify the cellular and subcellular localization of Nramp2 in normal tissues and to study possible regulation by dietary iron deprivation. Immunoblotting experiments with membrane fractions from intact organs show that Nramp2 is expressed at low levels throughout the small intestine and to a higher extent in kidney. Dietary iron starvation results in a dramatic upregulation of the Nramp2 isoform I in the proximal portion of the duodenum only, whereas expression in the rest of the small intestine and in kidney remains largely unchanged in response to the lack of dietary iron. In proximal duodenum, immunostaining studies of tissue sections show that Nramp2 protein expression is abundant under iron deplete condition and limited to the villi and is absent in the crypts. In the villi, staining is limited to the columnar absorptive epithelium of the mucosa (enterocytes), with no expression in mucus-secreting goblet cells or in the lamina propria. Nramp2 expression is strongest in the apical two thirds of the villi and is very intense at the brush border of the apical pole of the enterocytes, whereas the basolateral membrane of these cells is negative for Nramp2. These results strongly suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum. These findings are discussed in the context of overall mechanisms of iron acquisition by the body." @default.
• W4247376504 created "2022-05-12" @default.
• W4247376504 creator A5007887366 @default.
• W4247376504 creator A5042112338 @default.
• W4247376504 creator A5045348393 @default.
• W4247376504 creator A5056211046 @default.
• W4247376504 date "1999-06-15" @default.
• W4247376504 modified "2023-09-30" @default.
• W4247376504 title "Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron" @default.
• W4247376504 cites W1484563081 @default.
• W4247376504 cites W1495084227 @default.
• W4247376504 cites W1547673256 @default.
• W4247376504 cites W1559318172 @default.
• W4247376504 cites W1560884438 @default.
• W4247376504 cites W1568628619 @default.
• W4247376504 cites W15887191 @default.
• W4247376504 cites W1602078008 @default.
• W4247376504 cites W1603236380 @default.
• W4247376504 cites W165130051 @default.
• W4247376504 cites W1679948510 @default.
• W4247376504 cites W1970910747 @default.
• W4247376504 cites W1971609546 @default.
• W4247376504 cites W1974613058 @default.
• W4247376504 cites W1977826975 @default.
• W4247376504 cites W1990409762 @default.
• W4247376504 cites W1995022220 @default.
• W4247376504 cites W1998143976 @default.
• W4247376504 cites W2004186508 @default.
• W4247376504 cites W2006358233 @default.
• W4247376504 cites W2007644784 @default.
• W4247376504 cites W2015326313 @default.
• W4247376504 cites W2022836866 @default.
• W4247376504 cites W2023433008 @default.
• W4247376504 cites W2025234158 @default.
• W4247376504 cites W2037704190 @default.
• W4247376504 cites W2040519526 @default.
• W4247376504 cites W2040853225 @default.
• W4247376504 cites W2047283460 @default.
• W4247376504 cites W2047494295 @default.
• W4247376504 cites W2047501354 @default.
• W4247376504 cites W2053142040 @default.
• W4247376504 cites W2055844262 @default.
• W4247376504 cites W2059360897 @default.
• W4247376504 cites W2063428061 @default.
• W4247376504 cites W2063504630 @default.
• W4247376504 cites W2070236309 @default.
• W4247376504 cites W2072127906 @default.
• W4247376504 cites W2080057691 @default.
• W4247376504 cites W2082806735 @default.
• W4247376504 cites W2090401018 @default.
• W4247376504 cites W2094622862 @default.
• W4247376504 cites W2105426389 @default.
• W4247376504 cites W2110942360 @default.
• W4247376504 cites W2111107420 @default.
• W4247376504 cites W2114417847 @default.
• W4247376504 cites W2117592417 @default.
• W4247376504 cites W2120694471 @default.
• W4247376504 cites W2131215925 @default.
• W4247376504 cites W2137143414 @default.
• W4247376504 cites W2139105741 @default.
• W4247376504 cites W2139713761 @default.
• W4247376504 cites W2146903969 @default.
• W4247376504 cites W2174595058 @default.
• W4247376504 cites W2187929378 @default.
• W4247376504 cites W2256290806 @default.
• W4247376504 cites W2278020568 @default.
• W4247376504 cites W2343105403 @default.
• W4247376504 cites W2415323078 @default.
• W4247376504 cites W2417919723 @default.
• W4247376504 cites W2586457950 @default.
• W4247376504 cites W4241433620 @default.
• W4247376504 cites W4243151110 @default.
• W4247376504 cites W63436701 @default.
• W4247376504 doi "https://doi.org/10.1182/blood.v93.12.4406.412k21_4406_4417" @default.
• W4247376504 hasPublicationYear "1999" @default.
• W4247376504 type Work @default.
• W4247376504 citedByCount "16" @default.
• W4247376504 countsByYear W42473765042022 @default.
• W4247376504 countsByYear W42473765042023 @default.
• W4247376504 crossrefType "journal-article" @default.
• W4247376504 hasAuthorship W4247376504A5007887366 @default.
• W4247376504 hasAuthorship W4247376504A5042112338 @default.
• W4247376504 hasAuthorship W4247376504A5045348393 @default.
• W4247376504 hasAuthorship W4247376504A5056211046 @default.
• W4247376504 hasConcept C104317684 @default.
• W4247376504 hasConcept C126322002 @default.
• W4247376504 hasConcept C130316041 @default.
• W4247376504 hasConcept C153911025 @default.
• W4247376504 hasConcept C185592680 @default.
• W4247376504 hasConcept C190062978 @default.
• W4247376504 hasConcept C203014093 @default.
• W4247376504 hasConcept C204232928 @default.
• W4247376504 hasConcept C2776710925 @default.
• W4247376504 hasConcept C2776768029 @default.
• W4247376504 hasConcept C2776879804 @default.
• W4247376504 hasConcept C2776914184 @default.
• W4247376504 hasConcept C3019368612 @default.
• W4247376504 hasConcept C41625074 @default.

• next