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- W4247382536 abstract "Abstract We present a fluorescent prime editing and enrichment reporter (fluoPEER), which can be tailored to any genomic target site. This system rapidly and faithfully ranks the efficiency of prime edit guide RNAs (pegRNAs) and any prime editor protein, including novel variants with flexible PAM recognition. Successful reporter editing enriches for genomic editing. FluoPEER can be employed for efficient correction of patient cells and to elucidate cellular mechanisms needed for successful prime editing." @default.
- W4247382536 created "2022-05-12" @default.
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- W4247382536 date "2021-05-08" @default.
- W4247382536 modified "2023-10-15" @default.
- W4247382536 title "Mutation-specific reporter for the optimization and enrichment of prime editing" @default.
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- W4247382536 doi "https://doi.org/10.1101/2021.05.08.443062" @default.
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