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- W4247387632 abstract "Ten polycyclic derivatives related to ellipticine have been synthesised and tested for their intercalating, reverse transcriptase (RT) inhibitory and multidrug resistance efflux pump inhibitory properties. The intercalating activity and the RT inhibitory activity of the derivatives suggest that ellipticine analogues bind at an allosteric binding site on RT or that this inhibition could be controlled at the DNA level. The MDR efflux pump inhibitory activities of these derivatives, however, appears to be unrelated to the DNA binding ability." @default.
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- W4247387632 date "2001-09-01" @default.
- W4247387632 modified "2023-10-14" @default.
- W4247387632 title "Ellipticine analogues and related compounds as inhibitors of reverse transcriptase and as inhibitors of the efflux pump" @default.
- W4247387632 doi "https://doi.org/10.1002/1521-4184(200109)334:8/9<269::aid-ardp269>3.0.co;2-" @default.
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