FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247388220> ?p ?o ?g. }

• W4247388220 endingPage "29" @default.
• W4247388220 startingPage "27" @default.
• W4247388220 abstract "In cattle, the oviduct plays a fundamental role in the reproductive process. Oviductal functions are controlled by the ovarian sex steroids: estradiol and progesterone. Here, we tested the hypothesis that the exposure to contrasting sex steroid milieus differentially impacts the oviductal transcriptional profile. We manipulated growth of the pre-ovulatory follicle to obtain cows that ovulated a larger (LF group) or a smaller (SF group) follicle. The LF group presented greater proestrus/estrus concentrations of estradiol and metaestrus concentrations of progesterone (Gonella-Diaza et al. 2015 [1], Mesquita et al. 2014 [2]). Also, the LF group was associated with greater fertility in timed-artificial insemination programs (Pugliesi et al. 2016 [3]). Cows were slaughtered on day 4 of the estrous cycle and total RNA was extracted from ampulla and isthmus fragments and analyzed by RNAseq. The resulting reads were mapped to the bovine genome (Bos taurus UMD 3.1, NCBI). The differential expression analyses revealed that 325 and 367 genes in ampulla and 274 and 316 genes in the isthmus were up-regulated and down-regulated in LF samples, respectively. To validate the RNAseq results, transcript abundance of 23 genes was assessed by qPCR and expression patterns were consistent between the two techniques. A functional enrichment analysis was performed using Database for Annotation, Visualization and Integrated Discovery (DAVID) software. Processes enriched in the LF group included tissue morphology changes (extracellular matrix remodeling), cellular changes (proliferation), and secretion changes (growth factors, ions and metal transporters). An overview of the gene expression data was deposited in the NCBI's Gene Expression Omnibus (GEO) and is accessible through the accession number GSE65681. In conclusion, differences in the peri-ovulatory sex steroid milieu modify the oviductal gene expression profiles. Such differences may be associated with the greater fertility of the LF cows. This dataset is useful for further investigations of the oviductal biology and the impact of sex-steroid on the female reproductive tract." @default.
• W4247388220 created "2022-05-12" @default.
• W4247388220 creator A5025473237 @default.
• W4247388220 creator A5025886773 @default.
• W4247388220 creator A5033355969 @default.
• W4247388220 creator A5049650481 @default.
• W4247388220 creator A5062630916 @default.
• W4247388220 creator A5067077853 @default.
• W4247388220 creator A5076241242 @default.
• W4247388220 creator A5076503404 @default.
• W4247388220 creator A5078750369 @default.
• W4247388220 creator A5088000445 @default.
• W4247388220 date "2017-09-01" @default.
• W4247388220 modified "2023-10-14" @default.
• W4247388220 title "Oviductal transcriptional profiling of a bovine fertility model by next-generation sequencing" @default.
• W4247388220 cites W1938289443 @default.
• W4247388220 cites W2046425272 @default.
• W4247388220 cites W2108234281 @default.
• W4247388220 cites W2122683221 @default.
• W4247388220 cites W2140729960 @default.
• W4247388220 cites W2152239989 @default.
• W4247388220 cites W2160697532 @default.
• W4247388220 cites W2170551349 @default.
• W4247388220 cites W2209762229 @default.
• W4247388220 cites W2218211031 @default.
• W4247388220 doi "https://doi.org/10.1016/j.gdata.2017.06.004" @default.
• W4247388220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28664146" @default.
• W4247388220 hasPublicationYear "2017" @default.
• W4247388220 type Work @default.
• W4247388220 citedByCount "8" @default.
• W4247388220 countsByYear W42473882202018 @default.
• W4247388220 countsByYear W42473882202019 @default.
• W4247388220 countsByYear W42473882202021 @default.
• W4247388220 crossrefType "journal-article" @default.
• W4247388220 hasAuthorship W4247388220A5025473237 @default.
• W4247388220 hasAuthorship W4247388220A5025886773 @default.
• W4247388220 hasAuthorship W4247388220A5033355969 @default.
• W4247388220 hasAuthorship W4247388220A5049650481 @default.
• W4247388220 hasAuthorship W4247388220A5062630916 @default.
• W4247388220 hasAuthorship W4247388220A5067077853 @default.
• W4247388220 hasAuthorship W4247388220A5076241242 @default.
• W4247388220 hasAuthorship W4247388220A5076503404 @default.
• W4247388220 hasAuthorship W4247388220A5078750369 @default.
• W4247388220 hasAuthorship W4247388220A5088000445 @default.
• W4247388220 hasBestOaLocation W42473882201 @default.
• W4247388220 hasConcept C102570824 @default.
• W4247388220 hasConcept C104317684 @default.
• W4247388220 hasConcept C105702510 @default.
• W4247388220 hasConcept C126322002 @default.
• W4247388220 hasConcept C134018914 @default.
• W4247388220 hasConcept C150194340 @default.
• W4247388220 hasConcept C162317418 @default.
• W4247388220 hasConcept C16685009 @default.
• W4247388220 hasConcept C1998276 @default.
• W4247388220 hasConcept C2777129507 @default.
• W4247388220 hasConcept C2777522975 @default.
• W4247388220 hasConcept C2777702977 @default.
• W4247388220 hasConcept C54355233 @default.
• W4247388220 hasConcept C71315377 @default.
• W4247388220 hasConcept C71924100 @default.
• W4247388220 hasConcept C86803240 @default.
• W4247388220 hasConceptScore W4247388220C102570824 @default.
• W4247388220 hasConceptScore W4247388220C104317684 @default.
• W4247388220 hasConceptScore W4247388220C105702510 @default.
• W4247388220 hasConceptScore W4247388220C126322002 @default.
• W4247388220 hasConceptScore W4247388220C134018914 @default.
• W4247388220 hasConceptScore W4247388220C150194340 @default.
• W4247388220 hasConceptScore W4247388220C162317418 @default.
• W4247388220 hasConceptScore W4247388220C16685009 @default.
• W4247388220 hasConceptScore W4247388220C1998276 @default.
• W4247388220 hasConceptScore W4247388220C2777129507 @default.
• W4247388220 hasConceptScore W4247388220C2777522975 @default.
• W4247388220 hasConceptScore W4247388220C2777702977 @default.
• W4247388220 hasConceptScore W4247388220C54355233 @default.
• W4247388220 hasConceptScore W4247388220C71315377 @default.
• W4247388220 hasConceptScore W4247388220C71924100 @default.
• W4247388220 hasConceptScore W4247388220C86803240 @default.
• W4247388220 hasLocation W42473882201 @default.
• W4247388220 hasLocation W42473882202 @default.
• W4247388220 hasLocation W42473882203 @default.
• W4247388220 hasLocation W42473882204 @default.
• W4247388220 hasLocation W42473882205 @default.
• W4247388220 hasLocation W42473882206 @default.
• W4247388220 hasOpenAccess W4247388220 @default.
• W4247388220 hasPrimaryLocation W42473882201 @default.
• W4247388220 hasRelatedWork W1976500522 @default.
• W4247388220 hasRelatedWork W1977899557 @default.
• W4247388220 hasRelatedWork W2026499020 @default.
• W4247388220 hasRelatedWork W2033548259 @default.
• W4247388220 hasRelatedWork W2076264574 @default.
• W4247388220 hasRelatedWork W2078231188 @default.
• W4247388220 hasRelatedWork W2159247865 @default.
• W4247388220 hasRelatedWork W2172260038 @default.
• W4247388220 hasRelatedWork W2369400495 @default.
• W4247388220 hasRelatedWork W2606331344 @default.
• W4247388220 hasVolume "13" @default.
• W4247388220 isParatext "false" @default.
• W4247388220 isRetracted "false" @default.

• next