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• W4247402114 abstract "Free Access Boron oxide [MAK Value Documentation, 1999] 1999. Documentations and Methods First published: 31 January 2012 https://doi.org/10.1002/3527600418.mb130386e0013 AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Published in the series Occupational Toxicants, Vol. 13 (1999) The article contains sections titled: Effects in Man Animal Experiments Manifesto (MAK value/classification) MAK value not yet established; see Section IIb of the List of MAK and BAT Values Peak limitation - Absorption through the skin - Sensitization - Carcinogenicity - Prenatal toxicity - Germ cell mutagenicity - BAT value - Synonyms boric anhydride boron trioxide boric oxide boron sesquioxide Chemical name (CAS) boron oxide CAS number 1303–86–2 Molecular formula B2O3 Molecular weight 69.64 Melting point 450°C Boiling point 1500°C The previously valid MAK value for boron oxide of 15 mg/m3 (measured as the inhalable aerosol fraction) was established in 1966 in analogy to the TLV value at the time. The present documentation is based on a review of toxicological data on boron oxide by the ACGIH 1991. 1 Effects in Man The effects of boron oxide and boric acid were investigated in a study of 113 workers by evaluating questionnaires. The workers were exposed to average boron oxide and boric acid concentrations of 4.1 mg/m3 (range 1.2–8.5 mg/m3). Compared to the unexposed control collective (214 workers), the exposed workers complained more frequently of eye irritation, irritation of the upper respiratory passages, coughing and dryness in the mouth (Garabrant et al. 1984). 2 Animal Experiments The LD50 values for mice are about 3000 mg/kg body weight after oral administration of boron oxide and about 1900 mg/kg body weight after intraperitoneal administration. Topical application of boron oxide to the shaved dorsal skin of rabbits (40 mg/cm2) produced erythema which persisted for 2 to 3 days. Eye irritation was observed in rabbits after instillation of 50 mg boron oxide into the left eye (Wilding et al. 1959). Inhalation studies were carried out with rats exposed for 10 weeks to boron oxide concentrations of 470 mg/m3, for 12 weeks to 175 mg/m3 and for 24 weeks to 77 mg/m3. Concentrations of 77 mg/m3 led to unclear effects on urinary parameters, such as an increase in the urine volume, increased creatinine excretion and reduced pH. In the urine of these animals, a boron concentration of 11.9 mg/kg and day (controls 0.24 mg/kg and day) was measured. Slight irritation of the nose was observed after exposure to boron oxide concentrations from 470 mg/m3. Histopathological examination of all organs did not reveal any signs of toxicity (Wilding et al. 1959). Examination of the blood of dogs exposed to boron oxide concentrations of 57 mg/m3 for 23 weeks, did not reveal any substance-related changes (Wilding et al. 1959). 3 Manifesto (MAK value/classification) Exposure to boron oxide and its hydration product, boric acid, led in man to irritation of the eyes and upper respiratory tract. A threshold value cannot, however, be established from the data available. As also no NOAEL (no observed adverse effect level) can be deduced from the animal experiments carried out to investigate systemic toxicity, the previous MAK value has been withdrawn and boron oxide included in Section IIb of the List of MAK and BAT Values. References ACGIH (American Conference of Governmental Industrial Hygienists) (1991) Documentation of the threshold limit values and biological exposure indices, boron oxide, ACGIH, Cincinnati, Ohio Garabrant DH, Bernstein L, Peters JM, Smith TJ (1984) Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 26: 584– 586 Wilding JL, Smith WJ, Yevich P, Sicks ME, Ryan SG, Punte CL (1959) The toxicity of boron oxide. Am Ind Hyg Assoc J 20: 284– 289 The MAK-Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the WorkplaceBrowse other articles of this reference work:BROWSE TABLE OF CONTENTSBROWSE BY TOPIC ReferencesRelatedInformation" @default.
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• W4247402114 title "Boron oxide [MAK Value Documentation, 1999]" @default.
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