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- W4247423025 abstract "Sodium currents in cell lines transfected with the sole α-subunit, or constitutively expressing sodium channels, have an inactivation that is always prevalently mono-exponential. Differently, expression of α-subunit in Xenopus oocytes exerts slow inactivating currents with biphasic decay, while simultaneous co-transfection of α and β1 restores a mono-exponential (normal) inactivation. A hypothesis for such differences is that an endogenous presence of β1 or β1-alternative splicing, β1A, in cells could account for the normal inactivation. To test this hypothesis and to evaluate the role for the β1A, we inhibited the expression of β1/β1A by antisense oligonucleotides on Nav1.4-transfected human embryonic cell line 293 (HEK) cells. Reduction of β1/β1A produces no significant functional effects in Nav1.4-HEK. This result invalidates the hypothesis that the lack of slow-mode in cell lines is simply due to a constitutive expression of β1/β1A." @default.
- W4247423025 created "2022-05-12" @default.
- W4247423025 date "2005-04-01" @default.
- W4247423025 modified "2023-10-18" @default.
- W4247423025 title "fmv-vi - GUIDELINES FOR AUTHORS" @default.
- W4247423025 doi "https://doi.org/10.1016/s0304-3940(05)00346-0" @default.
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