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- W4247454146 abstract "Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki–Miyaura coupling reaction as a key step. Additionally, the structure–activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol." @default.
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- W4247454146 date "2004-05-01" @default.
- W4247454146 modified "2023-09-28" @default.
- W4247454146 title "Efficient synthesis and structure?activity relationship of honokiol, a neurotrophic biphenyl-type neolignan" @default.
- W4247454146 doi "https://doi.org/10.1016/s0960-894x(04)00287-2" @default.
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