Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247458000> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4247458000 abstract "Abstract Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are not fully understood. We identified that the voltage-gated proton channel Hv1, which is functionally expressed in spinal microglia, was significantly increased after spinal nerve transection (SNT). Hv1 mediated voltage-gated proton currents in spinal microglia and mice lacking Hv1 (Hv1 KO) display attenuated pain hypersensitivities after SNT compared with wildtype (WT) mice. In addition, microglial production of reactive oxygen species (ROS) and subsequent astrocyte activation in the spinal cord was reduced in Hv1 KO mice after SNT. Cytokine screening and immunostaining further revealed that IFN-γ expression was compromised in spinal astrocytes in Hv1 KO mice. These results demonstrate that Hv1 proton channel contributes to microglial ROS production, astrocyte activation, IFN-γ upregulation, and subsequent pain hypersensitivities after SNT. This study suggests Hv1-dependent microglia-astrocyte communication in pain hypersensitivities and identifies Hv1 as a novel therapeutic target for alleviating neuropathic pain." @default.
- W4247458000 created "2022-05-12" @default.
- W4247458000 creator A5004035910 @default.
- W4247458000 creator A5005357174 @default.
- W4247458000 creator A5015283451 @default.
- W4247458000 creator A5016038412 @default.
- W4247458000 creator A5026746873 @default.
- W4247458000 creator A5049466193 @default.
- W4247458000 creator A5050366896 @default.
- W4247458000 creator A5065460906 @default.
- W4247458000 creator A5068209902 @default.
- W4247458000 creator A5076977334 @default.
- W4247458000 creator A5078154869 @default.
- W4247458000 date "2021-05-05" @default.
- W4247458000 modified "2023-10-16" @default.
- W4247458000 title "The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury" @default.
- W4247458000 doi "https://doi.org/10.21203/rs.3.rs-479825/v1" @default.
- W4247458000 hasPublicationYear "2021" @default.
- W4247458000 type Work @default.
- W4247458000 citedByCount "0" @default.
- W4247458000 crossrefType "posted-content" @default.
- W4247458000 hasAuthorship W4247458000A5004035910 @default.
- W4247458000 hasAuthorship W4247458000A5005357174 @default.
- W4247458000 hasAuthorship W4247458000A5015283451 @default.
- W4247458000 hasAuthorship W4247458000A5016038412 @default.
- W4247458000 hasAuthorship W4247458000A5026746873 @default.
- W4247458000 hasAuthorship W4247458000A5049466193 @default.
- W4247458000 hasAuthorship W4247458000A5050366896 @default.
- W4247458000 hasAuthorship W4247458000A5065460906 @default.
- W4247458000 hasAuthorship W4247458000A5068209902 @default.
- W4247458000 hasAuthorship W4247458000A5076977334 @default.
- W4247458000 hasAuthorship W4247458000A5078154869 @default.
- W4247458000 hasBestOaLocation W42474580001 @default.
- W4247458000 hasConcept C134018914 @default.
- W4247458000 hasConcept C169760540 @default.
- W4247458000 hasConcept C185592680 @default.
- W4247458000 hasConcept C203014093 @default.
- W4247458000 hasConcept C2775991916 @default.
- W4247458000 hasConcept C2776880756 @default.
- W4247458000 hasConcept C2776914184 @default.
- W4247458000 hasConcept C2777107010 @default.
- W4247458000 hasConcept C2777542381 @default.
- W4247458000 hasConcept C2778334475 @default.
- W4247458000 hasConcept C2779830541 @default.
- W4247458000 hasConcept C2780775167 @default.
- W4247458000 hasConcept C2781149210 @default.
- W4247458000 hasConcept C42219234 @default.
- W4247458000 hasConcept C48349386 @default.
- W4247458000 hasConcept C529278444 @default.
- W4247458000 hasConcept C55493867 @default.
- W4247458000 hasConcept C71924100 @default.
- W4247458000 hasConcept C86803240 @default.
- W4247458000 hasConcept C87753298 @default.
- W4247458000 hasConceptScore W4247458000C134018914 @default.
- W4247458000 hasConceptScore W4247458000C169760540 @default.
- W4247458000 hasConceptScore W4247458000C185592680 @default.
- W4247458000 hasConceptScore W4247458000C203014093 @default.
- W4247458000 hasConceptScore W4247458000C2775991916 @default.
- W4247458000 hasConceptScore W4247458000C2776880756 @default.
- W4247458000 hasConceptScore W4247458000C2776914184 @default.
- W4247458000 hasConceptScore W4247458000C2777107010 @default.
- W4247458000 hasConceptScore W4247458000C2777542381 @default.
- W4247458000 hasConceptScore W4247458000C2778334475 @default.
- W4247458000 hasConceptScore W4247458000C2779830541 @default.
- W4247458000 hasConceptScore W4247458000C2780775167 @default.
- W4247458000 hasConceptScore W4247458000C2781149210 @default.
- W4247458000 hasConceptScore W4247458000C42219234 @default.
- W4247458000 hasConceptScore W4247458000C48349386 @default.
- W4247458000 hasConceptScore W4247458000C529278444 @default.
- W4247458000 hasConceptScore W4247458000C55493867 @default.
- W4247458000 hasConceptScore W4247458000C71924100 @default.
- W4247458000 hasConceptScore W4247458000C86803240 @default.
- W4247458000 hasConceptScore W4247458000C87753298 @default.
- W4247458000 hasLocation W42474580001 @default.
- W4247458000 hasOpenAccess W4247458000 @default.
- W4247458000 hasPrimaryLocation W42474580001 @default.
- W4247458000 hasRelatedWork W12270064 @default.
- W4247458000 hasRelatedWork W12919727 @default.
- W4247458000 hasRelatedWork W13385320 @default.
- W4247458000 hasRelatedWork W13814925 @default.
- W4247458000 hasRelatedWork W3153875 @default.
- W4247458000 hasRelatedWork W3857049 @default.
- W4247458000 hasRelatedWork W7706578 @default.
- W4247458000 hasRelatedWork W8792838 @default.
- W4247458000 hasRelatedWork W9243289 @default.
- W4247458000 hasRelatedWork W4199289 @default.
- W4247458000 isParatext "false" @default.
- W4247458000 isRetracted "false" @default.
- W4247458000 workType "article" @default.